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The adjunctive use of Leukocyte-Platelet Rich Fibrin (L-PRF) in the management of Medication Related Osteonecrosis of the Jaw (MRONJ): a retrospective observational study.
Aslam, Raj Dean; Pitros, Panagiotis; Liew, Jonathan; Besi, Eleni.
Afiliación
  • Aslam RD; Oral Surgery Department, Edinburgh Dental Institute, Lauriston Building, Lauriston Place, Edinburgh, EH3 9HA, UK. rajdeanaslam@gmail.com.
  • Pitros P; Oral Surgery Department, Edinburgh Dental Institute, Lauriston Building, Lauriston Place, Edinburgh, EH3 9HA, UK.
  • Liew J; Oral Surgery Department, Charles Clifford Dental Hospital, Wellesley Road, Sheffield, S10 2SZ, UK.
  • Besi E; Oral Surgery Department, Edinburgh Dental Institute, Lauriston Building, Lauriston Place, Edinburgh, EH3 9HA, UK.
Oral Maxillofac Surg ; 28(4): 1605-1615, 2024 Dec.
Article en En | MEDLINE | ID: mdl-39223310
ABSTRACT

PURPOSE:

Medication related osteonecrosis of the jaw (MRONJ) is a risk for patients taking anti-resorptive or anti-angiogenic medications. The American Association of Oral and Maxillofacial Surgeons (AAMOS) has classified MRONJ in stages to reflect the severity of the disease and allows implementation of suitable treatment pathways. MRONJ risk is < 5% in cancer patients and < 0.05% in osteoporosis patients. Management is subdivided into operative and non-operative, with advances in the literature investigating adjuvants. Leukocyte-Platelet Rich Fibrin (L-PRF) is an autologous biomaterial consisting of leukocytes and platelets embedded within a fibrin matrix with the ability to release growth factors enabling angiogenesis, bone regeneration and soft tissue healing. This paper's aim is to investigate the effects of L-PRF in conjuction with surgical debridement for management of MRONJ.

METHODS:

Twenty-two cases with established MRONJ were treated with either surgical intervention (Group A) or with surgical intervention and L-PRF (Group B), from 2016 to 2023 at Edinburgh Dental Institute (EDI). Treatments were deemed successful when the patients were asymptomatic, displayed complete soft tissue healing with the absence of infection/inflammation, fistula, or exposed bone.

RESULTS:

All cases in Group B had healed in contrast to 54.5% not healed in Group A; p value < 0.05 indicating statistical significance.

CONCLUSION:

The use of L-PRF as an adjuvant to surgical management of MRONJ is promising with its favourable functional capacity, simple application, and success of treatment outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteonecrosis de los Maxilares Asociada a Difosfonatos / Fibrina Rica en Plaquetas Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteonecrosis de los Maxilares Asociada a Difosfonatos / Fibrina Rica en Plaquetas Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania