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Revitalizing elixir with orange peel amplification of alginate fish oil beads for enhanced anti-aging efficacy.
Dhasmana, Archna; Preetam, Subham; Malik, Sumira; Jadon, Vikash Singh; Joshi, Nupur; Bhandari, Geeta; Gupta, Sanjay; Mishra, Richa; Rustagi, Sarvesh; Samal, Shailesh Kumar.
Afiliación
  • Dhasmana A; Himalayan School of Biosciences, Swami Rama Himalayan University, Swami Ram Nagar, Jollygrant, Dehradun, Uttarakhand, India, 248140. archnadhasmana@srhu.edu.in.
  • Preetam S; Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Dalseong-gun, Daegu, 42988, South Korea.
  • Malik S; Amity Institute of Biotechnology, Amity University Jharkhand, Ranchi, 834002, India. smalik@rnc.amity.edu.
  • Jadon VS; Himalayan School of Biosciences, Swami Rama Himalayan University, Swami Ram Nagar, Jollygrant, Dehradun, Uttarakhand, India, 248140.
  • Joshi N; Himalayan School of Biosciences, Swami Rama Himalayan University, Swami Ram Nagar, Jollygrant, Dehradun, Uttarakhand, India, 248140.
  • Bhandari G; Himalayan School of Biosciences, Swami Rama Himalayan University, Swami Ram Nagar, Jollygrant, Dehradun, Uttarakhand, India, 248140.
  • Gupta S; Himalayan School of Biosciences, Swami Rama Himalayan University, Swami Ram Nagar, Jollygrant, Dehradun, Uttarakhand, India, 248140.
  • Mishra R; Department of Computer Engineering, Parul Institute of Engineering and Technology ( PIET), Parul University, Ta. Waghodia, Vadodara, Gujarat, 391760, India.
  • Rustagi S; School of Applied and Life Sciences, Uttaranchal University, 22 Dehradun, Uttarakhand, India.
  • Samal SK; Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden. shailesh.samal@ki.se.
Sci Rep ; 14(1): 20404, 2024 09 02.
Article en En | MEDLINE | ID: mdl-39223248
ABSTRACT
The research introduces a novel method for creating drug-loaded hydrogel beads that target anti-aging, anti-oxidative, and anti-inflammatory effects, addressing the interconnected processes underlying various pathological conditions. The study focuses on the development of hydrogel beads containing anti-aging compounds, antioxidants, and anti-inflammatory drugs to effectively mitigate various processes. The synthesis, characterization and in vitro evaluations, and potential applications of these multifunctional hydrogel beads are discussed. A polymeric alginate-orange peel extract (11) hydrogel was synthesized for encapsulating fish oil. Beads prepared with variable fish oil concentrations (0.1, 0.3, and 0.5 ml) were characterized, showing no significant decrease in size i.e., 0.5 mm and a reduction in pore size from 23 to 12 µm. Encapsulation efficiency reached up to 98% within 2 min, with controlled release achieved upto 45 to 120 min with increasing oil concentration, indicating potential for sustained delivery. Fourier-transform infrared spectroscopy confirmed successful encapsulation by revealing peak shifting, interaction between constituents. In vitro degradation studies showed the hydrogel's biodegradability improved from 30 to 120 min, alongside anti-inflammatory, anti-oxidative, anti-collagenase and anti-elastase activities, cell proliferation rate enhanced after entrapping fish oil. In conclusion, the synthesized hydrogel beads are a promising drug delivery vehicle because they provide stable and effective oil encapsulation with controlled release for notable anti-aging and regenerative potential. Targeted delivery for inflammatory and oxidative stress-related illnesses is one set of potential uses. Further research may optimize this system for broader applications in drug delivery and tissue engineering.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Pescado / Hidrogeles / Alginatos / Antioxidantes Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Pescado / Hidrogeles / Alginatos / Antioxidantes Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido