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Expanding horizons in pulmonary hypertension management: A systematic review and meta-analysis of non-pharmacological interventions.
Albulushi, Arif; De Silva, Thihan D; Kashoub, Masoud; Tawfek, Ahmed; Shams, Ahmed; Al-Riyami, Adil; Al-Kindi, Fahad; Bader, Feras.
Afiliación
  • Albulushi A; Department of Adult Cardiology, National Heart Center, The Royal Hospital, Muscat, Oman. Electronic address: dr.albulushi@gmail.com.
  • De Silva TD; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.
  • Kashoub M; Division of Cardiology, Sultan Qaboos University Hospital, Muscat, Oman.
  • Tawfek A; Department of Adult Cardiology, National Heart Center, The Royal Hospital, Muscat, Oman.
  • Shams A; Department of Adult Cardiology, National Heart Center, The Royal Hospital, Muscat, Oman.
  • Al-Riyami A; Division of Chest Medicine, Sultan Qaboos University Hospital, Muscat, Oman.
  • Al-Kindi F; Division of Chest Medicine, Sultan Qaboos University Hospital, Muscat, Oman.
  • Bader F; Department of Cardiology, Heart, Vascular and Thoracic Institute, Cleveland Clinic Abu Dhabi, UAE.
Curr Probl Cardiol ; 49(12): 102825, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-39222831
ABSTRACT

BACKGROUND:

Pulmonary hypertension (PH) is a progressive and life-threatening disorder characterized by elevated pulmonary arterial pressure, leading to right heart failure and reduced exercise capacity. Traditional pharmacological and surgical treatments offer limited efficacy and significant side effects, necessitating the exploration of alternative therapeutic options.

OBJECTIVE:

This systematic review and meta-analysis aimed to evaluate the efficacy and safety of non-pharmacological interventions, including exercise, dietary modifications, and psychosocial therapies, in the management of pulmonary hypertension.

METHODS:

Comprehensive searches were conducted in PubMed, Cochrane Library, and Scopus up to 2024, identifying randomized controlled trials and observational studies examining non-pharmacological interventions for PH. Primary outcomes assessed included pulmonary arterial pressure, right heart function, exercise capacity, and quality of life, with secondary analysis on safety and adverse effects. Data synthesis was performed using random-effects meta-analysis.

RESULTS:

The review included 30 studies, totaling 2000 participants with various forms of PH. Meta-analysis demonstrated significant improvements in exercise capacity as measured by the 6 min walk distance (mean increase of 45 meters, 95 % CI 30-60, p<0.001), enhanced quality of life scores, and reduction in pulmonary arterial pressure (mean reduction of 5 mmHg, 95 % CI 3-7, p<0.01). Non-pharmacological therapies also showed a favorable safety profile, with minor adverse effects reported.

CONCLUSION:

Non-pharmacological interventions provide a viable and effective complement to traditional treatments for pulmonary hypertension, significantly improving functional capacity and hemodynamic parameters without severe adverse effects. These findings support the integration of tailored non-pharmacological strategies into the therapeutic regimen for PH patients, emphasizing the need for broader implementation and further research to optimize intervention protocols.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Probl Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Probl Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos