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Integrated PrEP and STI Services for Transgender Women in Uganda: Qualitative Findings from a Randomized Trial.
Mujugira, Andrew; Nakyanzi, Agnes; Bagaya, Monica; Mugisha, Jackson; Kamusiime, Brenda; Nalumansi, Alisaati; Kasiita, Vicent; Ssebuliba, Timothy; Nampewo, Olivia; Nsubuga, Rogers; Muwonge, Timothy R; Bukenya, Musa; Gandhi, Monica; Wyatt, Monique A; Ware, Norma C; Haberer, Jessica E.
Afiliación
  • Mujugira A; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda. amujugira@idi.co.ug.
  • Nakyanzi A; Department of Global Health, University of Washington, Seattle, WA, USA. amujugira@idi.co.ug.
  • Bagaya M; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Mugisha J; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Kamusiime B; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Nalumansi A; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Kasiita V; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Ssebuliba T; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Nampewo O; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Nsubuga R; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Muwonge TR; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Bukenya M; Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
  • Gandhi M; Kuchu Shiners Uganda, Kampala, Uganda.
  • Wyatt MA; Department of Medicine, University of California San Francisco, San Francisco, USA.
  • Ware NC; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Haberer JE; Harvard Global, Cambridge, MA, USA.
AIDS Behav ; 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39222182
ABSTRACT
Tenofovir alafenamide fumarate (F/TAF) pre-exposure prophylaxis (PrEP) is understudied in sub-Saharan Africa. The Tandika PrEP study was a randomized trial that evaluated same-day F/TAF initiation, the impact of drug-level feedback on PrEP adherence, and integrated PrEP and sexually transmitted infection (STI) services for HIV-negative transgender women (TGW) in Uganda (NCT04491422). From April 2022-February 2023, a qualitative sub-study of 30 in-depth interviews explored (1) perspectives on same-day initiation of F/TAF PrEP, (2) experiences of urine tenofovir testing and drug-level feedback, and (3) descriptions of self-collection of samples for STI testing. Qualitative data were analyzed using an inductive content analytic approach. Integrated PrEP/STI services were valued by TGW because the convenience of urine testing motivated adherence and allowed for tenofovir and STI detection. (1) Preferred characteristics F/TAF-based PrEP was easy to take and not readily identifiable as an HIV-related medication, resulting in less stigma than the better-known tenofovir disoproxil fumarate (F/TDF). Weight gain associated with F/TAF use was viewed positively by TGW as a symbol of health and prosperity in African settings. (2) Adherence motivation PrEP adherence was motivated by a desire not to disappoint healthcare workers; TGW reciprocated adherence support and drug-level feedback by taking PrEP. (3) Facilitating adherence and STI care Urine testing enhanced STI detection and treatment. Utilization of urine for tenofovir and STI testing motivated the uptake of HIV/STI care, emphasizing the importance of integrated PrEP and STI services. Integrating PrEP/STI services into differentiated delivery models could increase prevention uptake in this vulnerable population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: AIDS Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: AIDS Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Estados Unidos