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Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis.
Girardis, Massimo; David, Sascha; Ferrer, Ricard; Helms, Julie; Juffermans, Nicole P; Martin-Loeches, Ignacio; Povoa, Pedro; Russell, Lene; Shankar-Hari, Manu; Iba, Toshiaki; Coloretti, Irene; Parchim, Nicholas; Nielsen, Nathan D.
Afiliación
  • Girardis M; Anaesthesiology and Intensive Care Department, University Hospital of Modena, University of Modena, Reggio Emilia, Italy. girardis.massimo@unimore.it.
  • David S; Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland.
  • Ferrer R; Intensive Care Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Helms J; Université de Strasbourg (UNISTRA), Faculté de Médecine, Hôpitaux Universitaires de Strasbourg, Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Strasbourg, France.
  • Juffermans NP; Department of Intensive Care and Translational Laboratory of Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Martin-Loeches I; Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James' Hospital, Dublin, D08 NHY1, Ireland.
  • Povoa P; Hospital Clinic, Universitat de Barcelona, IDIBAPS, CIBERES, 08180, Barcelona, Spain.
  • Russell L; NOVA Medical School, NOVA University of Lisbon, Lisbon, Portugal.
  • Shankar-Hari M; Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, OUH Odense University Hospital, Odense, Denmark.
  • Iba T; Department of Intensive Care, Hospital de São Francisco Xavier, CHLO, Lisbon, Portugal.
  • Coloretti I; Copenhagen University Hospital Gentofte, Hellerup, Denmark.
  • Parchim N; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Nielsen ND; Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Intensive Care Med ; 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39222142
ABSTRACT
The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Intensive Care Med Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Intensive Care Med Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos