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Correlation of preoperative sonographic staging and postoperative histopathologic staging in patients with invasive breast cancer.
Mueller, Carolin; Zimmermann, Julia Sarah Maria; Radosa, Marc Philipp; Hahn, Anna Katharina; Kaya, Askin Canguel; Huwer, Sarah; Stotz, Lisa; Wagenpfeil, Gudrun; Radosa, Christoph Georg; Solomayer, Erich-Franz; Radosa, Julia Caroline.
Afiliación
  • Mueller C; Department of Gynecology, Obstetrics, and Reproductive Medicine, Saarland University Medical Center, 66421, Homburg, Saar, Germany.
  • Zimmermann JSM; Outcomes Research Consortium, Department of Anesthesiology, Cleveland Clinic, Cleveland, OH, 44195, USA.
  • Radosa MP; Department of Gynecology, Obstetrics, and Reproductive Medicine, Saarland University Medical Center, 66421, Homburg, Saar, Germany.
  • Hahn AK; Department of Gynecology and Obstetrics, Klinikum Bremen-Nord, Bremen, Germany.
  • Kaya AC; Department of Gynecology, Obstetrics, and Reproductive Medicine, Saarland University Medical Center, 66421, Homburg, Saar, Germany.
  • Huwer S; Department of Gynecology, Obstetrics, and Reproductive Medicine, Saarland University Medical Center, 66421, Homburg, Saar, Germany.
  • Stotz L; Department of Obstetrics & Gynecology, Medical Center-University of Freiburg, 79106, Freiburg, Germany.
  • Wagenpfeil G; Department of Gynecology, Obstetrics, and Reproductive Medicine, Saarland University Medical Center, 66421, Homburg, Saar, Germany.
  • Radosa CG; Institute for Medical Biometry, Epidemiology and Medical Informatics (IMBEI), Saarland University, Campus Homburg, 66421, Homburg, Germany.
  • Solomayer EF; Institute and Polyclinic of Diagnostic and Interventional Radiology, Medical University, TU Dresden, Dresden, Germany.
  • Radosa JC; Department of Gynecology, Obstetrics, and Reproductive Medicine, Saarland University Medical Center, 66421, Homburg, Saar, Germany.
Arch Gynecol Obstet ; 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39222087
ABSTRACT

PURPOSE:

To assess the accuracy of preoperative sonographic staging in patients with primary invasive breast cancer.

METHODS:

We retrospectively analyzed a prospectively kept service database of patients with newly diagnosed, unifocal, cT1-3, invasive breast cancer. All patients were diagnosed at a single center institution between January 2013 and December 2021. Clinical T stage was assessed preoperatively by ultrasound and correlated with the definite postoperative pathologic T stage. Demographics, clinical and pathological characteristics were collected. Factors influencing accuracy, over- and underdiagnosis of sonographic staging were analyzed with multivariable regression analysis.

RESULTS:

A total of 2478 patients were included in the analysis. Median patients' age was 65 years. 1577 patients (63.6%) had clinical T1 stage, 864 (34.9%) T2 and 37 (1.5%) T3 stage. The overall accuracy of sonography and histology was 76.5% (n = 1896), overestimation was observed in 9.1% (n = 225) of all cases, while underestimation occurred in 14.4% (n = 357) of all cases. Accuracy increased when clinical tumor stage cT was higher (OR 1.23; 95% CI 1.10-1.38, p ≤ 0.001). The highest accuracy was seen for patients with T2 stage (82.8%). The accuracy was lower in Luminal B tumors compared to Luminal A tumors (OR 0.71; 95% CI 0.59-0.87, p ≤ 0.001). We could not find any association between sonographic accuracy in HER2 positive patients, and demographic characteristics, or tumor-related factors.

CONCLUSION:

Our unicentric study showed a high accuracy of sonography in predicting T stage, especially for tumors with clinical T2 stage. Tumor stage and biological tumor factors do affect the accuracy of sonographic staging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania