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Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study.
Manocchio, Nicola; Ljoka, Concetta; Piacentini, Nicolò; Sorge, Roberto; Vita, Giulia; Foti, Calogero.
Afiliación
  • Manocchio N; Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor Vergata. nicola.manocchio@uniroma2.it.
  • Ljoka C; Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor Vergata, Italy; Physical and Rehabilitation Medicine Unit, Tor Vergata University Hospital, Rome. concetta.ljoka@ptvonline.it.
  • Piacentini N; Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor Vergata. nicolo.piacentini@students.uniroma2.eu.
  • Sorge R; Systems Medicine, Biometric Unit, University of Rome Tor Vergata. sorge@uniroma2.it.
  • Vita G; Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor Vergata. giulia.vita@students.uniroma2.eu.
  • Foti C; Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor Vergata, Italy; Physical and Rehabilitation Medicine Unit, Tor Vergata University Hospital, Rome. foti@med.uniroma2.it.
Eur J Transl Myol ; 34(3)2024 Aug 22.
Article en En | MEDLINE | ID: mdl-39221582
ABSTRACT
Osteoarthritis (OA) is a disabling disease that causes pain and functional limitation. OA symptoms can be treated with intra-articular injections of anti-inflammatory, viscosupplementary, or viscoinductive products. Non-responders to these approaches have limited options, often surgical (e.g. knee replacement). This retrospective study aims to evaluate the efficacy of a single injection of Carboxymethyl-Chitosan for advanced (Kellgren-Lawrence ≥3) and symptomatic knee OA in non-responders to hyaluronic acid. We enrolled 10 patients (5 female, 5 male). Treatment efficacy was assessed through the Visual Analogue Scale (VAS, pain) and the Knee Injury and Osteoarthritis Outcome Score (KOOS, knee function). Data are acquired from rating scales were administered at the time of injection (T0), one month (T1), three months (T2), and six months (T3) after treatment as for clinical practice. Results showed a significant improvement in pain and function at T1, with a subsequent gradual resumption of symptoms. In conclusion, the treatment showed a better outcome in the short term (i.e. up to 1 month after treatment); however, raw values of VAS and KOOS did not return to baseline levels showing a maintenance of improvement albeit not statistically significant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Transl Myol Año: 2024 Tipo del documento: Article Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Transl Myol Año: 2024 Tipo del documento: Article Pais de publicación: Italia