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Trajectories of CD4 T-cell count, CD8 T-cell count, and CD4/CD8 ratio in patients with HIV and long-term virological suppression based on Yunnan HIV cohort.
Shu, Yuanlu; Zhang, Mi; Li, Jianjian; Deng, Xuemei; Liu, Jiafa; Yang, Cuixian; Dong, Xingqi.
Afiliación
  • Shu Y; Department of Laboratory Medicine, The Affiliated Hospital of Infectious Diseases of Kunming Medical University, Kunming, China.
  • Zhang M; Department of Laboratory Medicine, Yunnan Provincial Infectious Disease Hospital, Kunming, China.
  • Li J; Department of Laboratory Medicine, The Affiliated Hospital of Infectious Diseases of Kunming Medical University, Kunming, China.
  • Deng X; Department of Laboratory Medicine, Yunnan Provincial Infectious Disease Hospital, Kunming, China.
  • Liu J; Department of Laboratory Medicine, The Affiliated Hospital of Infectious Diseases of Kunming Medical University, Kunming, China.
  • Yang C; Department of Laboratory Medicine, Yunnan Provincial Infectious Disease Hospital, Kunming, China.
  • Dong X; Department of Laboratory Medicine, The Affiliated Hospital of Infectious Diseases of Kunming Medical University, Kunming, China.
HIV Med ; 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39221521
ABSTRACT

OBJECTIVE:

Our objective was to evaluate the trajectory of immunology in patients with HIV with different baseline CD4 T-cell count strata after antiretroviral therapy (ART) under long-term viral suppression.

METHODS:

This was a sub-analysis focused on patients with virological suppression for at least 5 years after ART. Data were obtained from the Yunnan HIV cohort in China. Patients were categorized according to prespecified baseline CD4 T-cell counts. The trajectories of CD4 T-cell count, CD8 T-cell count, and CD4/CD8 ratio changing over time were fitted using a B-spline regression model. The Cox proportional hazards regression model was used to assess the association of baseline CD4 T-cell count with the risk of both immunological responder (IR) and CD4/CD8 ratio normalization.

RESULTS:

A total of 2618 patients with a median follow-up of 7.25 years (interquartile range [IQR] 5.92-8.75) were included. Over a period of 12 years, the mean CD4 T-cell count remained above 500 cells/µL in all groups. The mean CD4/CD8 ratio was solely normalized in patients whose baseline CD4 T-cell counts were above 350 cells/µL. Patients with higher baseline CD4 T-cell counts showed higher risks of both IR and CD4/CD8 ratio normalization than those with the lowest (all p trend <0.001). A higher baseline CD4 T-cell count predicted a shorter time for both IR and CD4/CD8 ratio normalization.

CONCLUSIONS:

Long-term, sustained viral suppression may not be able to fully normalize immunological functions in patients with HIV. A high baseline CD4 T-cell count benefits IR and CD4/CD8 ratio normalization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: HIV Med Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: HIV Med Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido