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A biomimic anti-neuroinflammatory nanoplatform for active neutrophil extracellular traps targeting and spinal cord injury therapy.
Tang, Chunming; Jin, Yaoyao; Wu, Min; Jia, Feng; Lu, Xiaowei; Li, Jinyu; Wu, Jie; Zhu, Senlin; Wang, Zhiji; An, Di; Xiong, Wu; Zhang, Yongjie; Xu, Huae; Chen, Xufeng.
Afiliación
  • Tang C; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
  • Jin Y; Department of Emergency, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, 223022, China.
  • Wu M; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
  • Jia F; Department of Neurosurgery, Yancheng NO.1 People's Hospital, The Affiliated Yancheng First Hospital of Nanjing University Medical School, Yancheng, 224008, China.
  • Lu X; Department of Geriatric Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
  • Li J; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
  • Wu J; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
  • Zhu S; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
  • Wang Z; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
  • An D; Department of Emergency Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
  • Xiong W; Department of Human Anatomy, Nanjing Medical University, Nanjing, 211166, China.
  • Zhang Y; Department of Human Anatomy, Nanjing Medical University, Nanjing, 211166, China.
  • Xu H; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
  • Chen X; Department of Emergency Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Mater Today Bio ; 28: 101218, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39221206
ABSTRACT
Traumatic spinal cord injury (SCI) always leads to severe neurological deficits and permanent damage. Neuroinflammation is a vital process of SCI and have become a promising target for SCI treatment. However, the neuroinflammation-targeted therapy would hinder the functional recovery of spinal cord and lead to the treatment failure. Herein, a biomimic anti-neuroinflammatory nanoplatform (DHCNPs) was developed for active neutrophil extracellular traps (NETs) targeting and SCI treatment. The curcumin-loaded liposome with the anti-inflammatory property acted as the core of the DHCNPs. Platelet membrane and neutrophil membrane were fused to form the biomimic hybrid membrane of the DHCNPs for hijacking neutrophils and neutralizing the elevated neutrophil-related proinflammatory cytokines, respectively. DNAse I modification on the hybrid membrane could achieve NETs degradation, blood spinal cord barrier, and neuron repair. Further studies proved that the DHCNPs could reprogram the multifaceted neuroinflammation and reverse the SCI process via nuclear factor kappa-B (NF-κB) pathway. We believe that the current study provides a new perspective for neuroinflammation inhibition and may shed new light on the treatment of SCI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido