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Rapid Tissue Perfusion Using Sacrificial Percolation of Anisotropic Networks.
Lammers, Alex; Hsu, Heng-Hua; Sundaram, Subramanian; Gagnon, Keith A; Kim, Sudong; Lee, Joshua H; Tung, Yi-Chung; Eyckmans, Jeroen; Chen, Christopher S.
Afiliación
  • Lammers A; The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
  • Hsu HH; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
  • Sundaram S; Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan.
  • Gagnon KA; The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
  • Kim S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
  • Lee JH; The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
  • Tung YC; The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
  • Eyckmans J; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
  • Chen CS; The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Matter ; 7(6): 2184-2204, 2024 Jun 05.
Article en En | MEDLINE | ID: mdl-39221109
ABSTRACT
Tissue engineering has long sought to rapidly generate perfusable vascularized tissues with vessel sizes spanning those seen in humans. Current techniques such as biological 3D printing (top-down) and cellular self-assembly (bottom-up) are resource intensive and have not overcome the inherent tradeoff between vessel resolution and assembly time, limiting their utility and scalability for engineering tissues. We present a flexible and scalable technique termed SPAN - Sacrificial Percolation of Anisotropic Networks, where a network of perfusable channels is created throughout a tissue in minutes, irrespective of its size. Conduits with length scales spanning arterioles to capillaries are generated using pipettable alginate fibers that interconnect above a percolation density threshold and are then degraded within constructs of arbitrary size and shape. SPAN is readily used within common tissue engineering processes, can be used to generate endothelial cell-lined vasculature in a multi-cell type construct, and paves the way for rapid assembly of perfusable tissues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Matter Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Matter Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos