Your browser doesn't support javascript.
loading
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis.
Liu, Baolong; Nguyen, Phuong Linh; Yu, Han; Li, Xingzhi; Wang, Huiren; Nguyen, Tram Gia Bao; Sahoo, Prakash Kumar; Sur, Meghna; Reddy, Jay; Sillman, Sarah; Kachman, Stephen D; Altartouri, Bara; Lu, Guoqing; Natarajan, Sathish Kumar; Pattabiraman, Mahesh; Yu, Jiujiu.
Afiliación
  • Liu B; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Nguyen PL; Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
  • Yu H; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Li X; Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Wang H; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Nguyen TGB; Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Sahoo PK; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Sur M; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Reddy J; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Sillman S; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Kachman SD; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Altartouri B; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Lu G; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Natarajan SK; Department of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Pattabiraman M; Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
  • Yu J; Department of Biology, University of Nebraska Omaha, Omaha, NE 68182, USA.
Acta Pharm Sin B ; 14(8): 3661-3679, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39220874
ABSTRACT
Non-alcoholic steatohepatitis (NASH), an advanced form of non-alcoholic fatty liver disease (NAFLD), has emerged as the leading cause of liver failure and related death. Currently, no medication is specifically approved to treat NAFLD or NASH. Here we report that oral administration of honey vesicle-like nanoparticles (H-VLNs) to naturally aged mice protects the liver from NASH development. H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged mice. Besides their reported anti-inflammasome function, H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B (NF-κB). MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-κB pathways. Collectively, oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos