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Incidence, surgical eligibility and outcome of spontaneous intracerebral haemorrhage in Southwest Finland - A retrospective study.
Lehto, Sami; Sajanti, Antti; Hellström, Santtu; Koskimäki, Fredrika; Srinath, Abhinav; Bennett, Carolyn; Carrión-Penagos, Julián; Cao, Ying; Jänkälä, Miro; Girard, Romuald; Rinne, Jaakko; Rahi, Melissa; Koskimäki, Janne.
Afiliación
  • Lehto S; Neurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
  • Sajanti A; Neurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
  • Hellström S; Neurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
  • Koskimäki F; Neurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
  • Srinath A; Medical Research Center, Research Unit of Clinical Medicine, University of Oulu, Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.
  • Bennett C; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
  • Carrión-Penagos J; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
  • Cao Y; Department of Neurology, University of Chicago Medicine and The University of Chicago, IL, USA.
  • Jänkälä M; Department of Radiation Oncology, Kansas University Medical Center, Kansas City, KS, USA.
  • Girard R; Department of Neurosurgery, Oulu University Hospital and University of Oulu, Finland.
  • Rinne J; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
  • Rahi M; Neurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
  • Koskimäki J; Neurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
Brain Spine ; 4: 102914, 2024.
Article en En | MEDLINE | ID: mdl-39220414
ABSTRACT

Introduction:

Spontaneous intracerebral haemorrhage (sICH) is a major cause of morbidity and mortality. Large-scale trials have shown neutral outcomes for surgical interventions. The recent trial suggested functional benefits from surgical intervention. Surgical treatment for sICH is likely increasing. Research question To determine the incidence of sICH in Southwest Finland, standardized to the European population, and to identify the proportion of large sICH patients eligible for surgery based on previously published trial criteria. We also examined factors associated with outcomes, including the effects of anticoagulant and antithrombotic medications. Material and

methods:

A retrospective clinical study identified 596 ICH cases treated at Turku University Hospital (2018-2019), of which 286 were supratentorial sICHs. Variables were analysed using a t-test, chi-squared or Fisher's exact test. A multivariate logistic modelling was performed to evaluate outcome differences.

Results:

The sICH incidence was 29.9/100,000 persons per year, with the highest European population age and sex standardized rates in individuals over 80 years old (110/100,000 males, 142/100,000 females). The incidence of sICH patients meeting surgical criteria was 2.7/100,000 persons per year. Out of 286 patients, 26 were eligible for surgery and had unfavourable outcomes (p = 0.0049). Multivariate analysis indicated a significant decrease in favourable outcomes with warfarin (p = 0.016, OR 0.42) and direct-acting anticoagulants (DOACs) (p = 0.034, OR 0.38), while antithrombotic medications showed no significant effect. Discussion and

conclusion:

We identified comparable incidence of sICH as European average. A small proportion of sICH cases were identified to be candidates for surgical intervention. Anticoagulants were associated with increased risk of unfavourable outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Spine Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Spine Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Países Bajos