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Characterisation and distribution of human coronary artery innervation.
Tokcan, Mert; Federspiel, Jan; Lauder, Lucas; Hohl, Mathias; Al Ghorani, Hussam; Kulenthiran, Saarraaken; Bettink, Stephanie; Böhm, Michael; Scheller, Bruno; Tschernig, Thomas; Mahfoud, Felix.
Afiliación
  • Tokcan M; Klinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany.
  • Federspiel J; Institute of Legal Medicine, Saarland University, Faculty of Medicine, Homburg, Germany.
  • Lauder L; Klinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany.
  • Hohl M; Department of Cardiology, University Heart Center, University Hospital Basel, Basel, Switzerland.
  • Al Ghorani H; Cardiovascular Research Institute Basel (CRIB), University Heart Center, University Hospital Basel, Basel, Switzerland.
  • Kulenthiran S; Klinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany.
  • Bettink S; Klinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany.
  • Böhm M; Klinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany.
  • Scheller B; Department of Cardiology, University Heart Center, University Hospital Basel, Basel, Switzerland.
  • Tschernig T; Klinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany.
  • Mahfoud F; Klinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany.
EuroIntervention ; 20(17): e1107-e1117, 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39219360
ABSTRACT

BACKGROUND:

A detailed understanding of the sympathetic innervation of coronary arteries is relevant to facilitate the development of novel treatment approaches.

AIMS:

This study aimed to quantitatively examine periarterial innervation in human epicardial coronary arteries.

METHODS:

Coronary arteries with adjacent epicardial adipose tissue were excised along the left main coronary artery (LMCA), left anterior descending artery (LAD), left circumflex artery (LCx), and right coronary artery (RCA) from 28 body donors and examined histologically. Immunofluorescence staining was performed to characterise sympathetic nerve fibres.

RESULTS:

A total of 42,573 nerve fibres surrounding 100 coronary arteries (LMCA n=21, LAD n=27, LCx n=26, RCA n=26) were analysed. The nerve fibre diameter decreased along the vessel course (median [interquartile range]) (proximal 46 µm [31-73], middle 38 µm [26-58], distal 31 µm [22-46]; p<0.001), with the largest nerve fibre diameter along the LMCA (50 µm [31-81]), followed by the LAD (42 µm [27-72]; p<0.001). The total nerve fibre density was highest along the RCA (123 nerves/cm² [82-194]). Circumferentially, nerve density was higher in the myocardial tissue area of the coronary arteries (132 nerves/cm² [76-225]) than in the epicardial tissue area (101 nerves/cm² [61-173]; p<0.001). The median lumen-nerve distance was smallest around the LMCA (2.2 mm [1.2-4.1]), followed by the LAD (2.5 mm [1.1-4.5]; p=0.005).

CONCLUSIONS:

Human coronary arteries are highly innervated with sympathetic nerve fibres, with significant variation in the distribution and density. Understanding these patterns informs pathophysiological understanding and, potentially, the development of catheter-based approaches for cardiac autonomic modulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Coronarios Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: EuroIntervention Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Coronarios Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: EuroIntervention Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Francia