The role of lncRNA binding to RNAbinding proteins to regulate mRNA stability in cancer progression and drug resistance mechanisms (Review).
Oncol Rep
; 52(5)2024 Nov.
Article
en En
| MEDLINE
| ID: mdl-39219266
ABSTRACT
Cancer is a disease that poses a serious threat to human health, the occurrence and development of which involves complex molecular mechanisms. Long noncoding RNAs (lncRNAs) and RNAbinding proteins (RBPs) are important regulatory molecules within cells, which have garnered extensive attention in cancer research in recent years. The binding of lncRNAs and RBPs plays a crucial role in the posttranscriptional regulation of mRNA, affecting the synthesis of proteins related to cancer by regulating the stability of mRNA. This, in turn, regulates the malignant biological behaviors of tumor cells, such as proliferation and metastasis, and serves an important role in therapeutic resistance. The present study reviewed the role of lncRNARBP interactions in the regulation of mRNA stability in various malignant tumors, with a focus on the molecular mechanisms underlying this regulatory interaction. The aim of the present review was to gain a deeper understanding of these molecular mechanisms to provide new strategies and insights for the precise treatment of cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
Regulación Neoplásica de la Expresión Génica
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Proteínas de Unión al ARN
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Progresión de la Enfermedad
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Resistencia a Antineoplásicos
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Estabilidad del ARN
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ARN Largo no Codificante
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Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Oncol Rep
Asunto de la revista:
NEOPLASIAS
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Grecia