Your browser doesn't support javascript.
loading
Comparison of Amiodarone Loading Dosage in the Treatment of Postoperative Atrial Fibrillation: High Versus Standard Dose Treatment.
Sariçam, Ersin; Öcal, Arslan; Iscanli, Murat Dogan; Bozkurt, Engin; Ilkay, Erdogan; Cantekin, Ömer Faruk.
Afiliación
  • Sariçam E; Cardiology Clinic, Medicana International Ankara Hospital, Atilim University, Ankara, Turkey.
  • Öcal A; Cardiology Clinic, Saglik Bilimleri University, Gülhane Egitim ve Arastirma Hastanesi, Ankara, Turkey.
  • Iscanli MD; Emergency Department, Medicana International Ankara Hospital, Atilim University, Ankara, Turkey.
  • Bozkurt E; Cardiology Clinic, Medicana International Ankara Hospital, Ankara, Turkey.
  • Ilkay E; Cardiology Clinic, Medicana International Ankara Hospital, Cardiology Clinic, Ankara, Turkey.
  • Cantekin ÖF; Department of Social Work, Faculty of Health Sciences, Gazi University, Ankara, Turkey.
Curr Vasc Pharmacol ; 2024 Aug 29.
Article en En | MEDLINE | ID: mdl-39219115
ABSTRACT

BACKGROUND:

Postoperative atrial fibrillation (POAF) is associated with poor outcomes, including hemodynamic instability, stroke, myocardial infarction, and death. In hemodynamic stable patients, the rhythm-control strategy is more advantageous than rate control. Current standard intravenous amiodarone administration has limited success and a delayed effect; the acute success rate is 44% (8-12 h to several days).

PURPOSE:

The aim of this study was to evaluate the effectiveness of higher amiodarone loading dosage to restore sinus rhythm in patients with POAF after noncardiac surgery.

METHODS:

This is a prospective, randomized, controlled single-center study. The study included 39 patients with POAF, divided into group I (n=27) (intravenous 600 mg amiodarone loading dosage over 2 h and infusion of 50 mg/h over a 24-h period) and group II (n=12) (standard protocol; 300 mg of bolus intravenously in 30 min and infusion of 50 mg/h over a 24-h period). The primary endpoint of the study was a restoration of sinus rhythm at the 24th hour.

RESULTS:

Baseline clinical, laboratory and echocardiographic characteristics of both groups were similar. The patients with higher loading amiodarone dosage had earlier restoration of sinus rhythm (2.38±1.41 vs 8.66±2.87 h, respectively; p=0.015). There was no significant difference in achieving sinus rhythm at the 24th hour between both groups.

CONCLUSION:

Higher loading amiodarone dosage increased early conversions to sinus rhythm compared with standard amiodarone protocol in patients with POAF.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Vasc Pharmacol Asunto de la revista: ANGIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Vasc Pharmacol Asunto de la revista: ANGIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Emiratos Árabes Unidos