Your browser doesn't support javascript.
loading
Determination of body composition by dual x-ray absorptiometry in persons with haemophilia.
Ransmann, Pia; Brühl, Marius; Hmida, Jamil; Goldmann, Georg; Oldenburg, Johannes; Strauss, Anna Christina; Hagedorn, Thorsten; Schildberg, Frank Alexander; Hilberg, Thomas; Strauss, Andreas Christian.
Afiliación
  • Ransmann P; Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
  • Brühl M; Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
  • Hmida J; Department of Orthopedics and Trauma Surgery, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany.
  • Goldmann G; Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
  • Oldenburg J; Department of Orthopedics and Trauma Surgery, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany.
  • Strauss AC; Institute for Experimental Haematology and Transfusion Medicine, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany.
  • Hagedorn T; Institute for Experimental Haematology and Transfusion Medicine, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany.
  • Schildberg FA; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany.
  • Hilberg T; Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
  • Strauss AC; Department of Orthopedics and Trauma Surgery, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany.
Haemophilia ; 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-39219066
ABSTRACT

BACKGROUND:

There is limited research on body composition in persons with haemophilia (PwH). The literature describes an increased body fat distribution and decreased lean mass in PwH compared to healthy controls using bioimpedance analysis. Using dual x-ray absorptiometry (DXA), which is known to be the most accurate method, this investigation aims to postulate reference data for body composition parameters within haemophilia severity phenotypes and age groups.

METHODS:

Persons underwent whole body DXA screening using Horizon. Body fat percentage, estimated visceral adipose tissue (VAT), appendicular fat and lean mass, and lean and fat mass in relation to body height were assessed. Haemophilia severity and five age groups were distinguished.

RESULTS:

Two hundred and one persons with mild (n = 44), moderate (n = 41), or severe (n = 116) haemophilia A/B (median age 40 [28-55; 1.IQ-3.IQ] years) were analysed. The median body fat percentage was 28.7% [25.5%-33.9%] and median estimated VAT was 657 g [403-954 g] with no significant difference between severity phenotypes (p = .474; p = .781). Persons with severe haemophilia had less lean mass compared to moderate and mild haemophilia (p = .013; p = .034). Total and appendicular fat is increased in older PwH (aged ≥40 years) compared to younger PwH (aged ≤29 years; p < .05). Lean mass did not differ between age groups.

CONCLUSION:

This study provides valuable reference data for body composition parameters in PwH. Persons with severe haemophilia show significantly less lean mass compared to persons with moderate or mild haemophilia. Body fat percentage and VAT did not differ between severity phenotypes, but increased with age.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Haemophilia Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Haemophilia Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido