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Review of Hydroxypropyl Methylcellulose in Artificial Tears for the Treatment of Dry Eye Disease.
Mysen, O Martin B; Hynnekleiv, Leif; Magnø, Morten S; Vehof, Jelle; Utheim, Tor P.
Afiliación
  • Mysen OMB; Department of Ear, Nose and Throat, Østfold Hospital Trust, Kalnes, Moss, Norway.
  • Hynnekleiv L; Department of Ophthalmology, Division of Head, Neck and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.
  • Magnø MS; Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Hospital, London, UK.
  • Vehof J; Department of Computer Science, Oslo Metropolitan University, Oslo, Norway.
  • Utheim TP; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.
Acta Ophthalmol ; 2024 09 01.
Article en En | MEDLINE | ID: mdl-39219040
ABSTRACT
Dry eye disease (DED) is a highly prevalent condition, resulting in reduced quality of life, lower participation in social life and impaired work efficiency. Hydroxypropyl methylcellulose (HPMC) is a cellulose-based viscosity-enhancing agent and is one of the most popular therapeutic ingredients in artificial tears. This review aims to evaluate the literature on the efficacy and safety of HPMC used in the treatment of DED. Literature searches were conducted in PubMed and Cochrane CENTRAL. A total of 28 clinical trials from 26 publications are included in this review, including 21 clinical intervention studies evaluating the effect of HPMC treatment over time and seven single instillation studies evaluating the short-term physical and symptomatic effects of HPMC after drop-instillation. The duration of clinical intervention studies ranged from 2 weeks to 5.5 months. DED severity ranged from mild to severe. Drop frequency ranged from two to up to 16 drops per day. HPMC concentration in artificial tears ranged from 0.2% to 0.5%. No major complications or adverse events were reported. Artificial tears containing HPMC were effective at improving symptoms and some signs of DED. However, combination drops with HPMC plus other therapeutic ingredients seem more effective than HPMC alone. HPMC appears to be equally effective or inferior to hyaluronic acid (HA). There is no evidence of superiority or inferiority to either carboxymethylcellulose (CMC) or polyethylene glycol 400/propylene glycol (PEG/PG). No single study explained the choice of drop frequency or HPMC concentration. More well-designed studies are needed to determine an evidence-based standard for HPMC treatment, including drop frequency, concentration and molecular weight for different DED severity and subgroups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido