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Factors influencing prophylactic surgical intervention in women with genetic predisposition for breast cancer.
Humar, Pooja; Balogun, Zainab; Douglas, Nerone; Glenney, Anne; Kass, Nicolás M; Moroni, Elizabeth A; Mai, Phuong L; Diego, Emilia; De La Cruz, Carolyn.
Afiliación
  • Humar P; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Balogun Z; Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Douglas N; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Glenney A; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Kass NM; Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Moroni EA; Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Mai PL; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Diego E; Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • De La Cruz C; Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
J Surg Oncol ; 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-39219039
ABSTRACT

INTRODUCTION:

In the United States, 5%-10% of breast cancer cases are due to genetic predisposition. Among this population, prophylactic mastectomy is viable risk-reducing option.

OBJECTIVE:

The objective of this study is to understand the timing to prophylactic mastectomy in patients with genetic predisposition to breast cancer and uncover factors influencing this decision.

METHODS:

This study is a retrospective review of patients diagnosed with genetic predisposition for breast cancer from 2010 to 2020.

RESULTS:

In a cohort of 506 patients with genetic predisposition for breast cancer, 154 (30.4%) underwent prophylactic mastectomy, the remainder opted for surveillance alone. The median time from diagnosis to mastectomy was 1.1 years (IQR, 0.5-3.1 years). During the surveillance period, 118 patients (33.5%) underwent breast biopsy. Of the patients with benign or atypical findings, 35 (36.8%) pursued prophylactic mastectomy, a median of 0.5 years (IQR, 0.2-1.6 years) after their gene diagnosis. The most common factor impacting the decision to undergo prophylactic mastectomy was having a family member with cancer (54.7%) followed by a personal diagnosis of other cancer(s) (27.5%).

CONCLUSION:

Understanding the factors influencing the decision to undergo prophylactic surgery will allow for more effective shared decision-making for primary care providers, breast surgeons, and reconstructive surgeons.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos