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Cortical high-frequency oscillations (≈ 110 Hz) in cats are state-dependent and enhanced by a subanesthetic dose of ketamine.
Castro-Zaballa, Santiago; González, Joaquín; Cavelli, Matías; Mateos, Diego; Pascovich, Claudia; Tort, Adriano; Hunt, Mark Jeremy; Torterolo, Pablo.
Afiliación
  • Castro-Zaballa S; Laboratorio de Neurobiología del Sueño, Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Electronic address: scastro@fmed.edu.uy.
  • González J; Laboratorio de Neurobiología del Sueño, Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Cavelli M; Laboratorio de Neurobiología del Sueño, Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Department of Psychiatry, University of Wisconsin, Madison, United States.
  • Mateos D; Consejo Nacional Investigaciones Científicas y Técnicas (CONICET), Argentina; Universidad Autónoma de Entre Ríos (FCyT-UADER), Entre Ríos, Argentina; Instituto de Matemática Aplicada del Litoral (IMAL-CONICET-UNL), Santa Fe, Argentina; Achucarro Basque Centre for Neuroscience, Spain.
  • Pascovich C; Laboratorio de Neurobiología del Sueño, Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Consciousness and Cognition Laboratory, Department of Psychology, University of Cambridge, United Kingdom.
  • Tort A; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Hunt MJ; Nencki Institute of Experimental Biology, Warsaw, Poland.
  • Torterolo P; Laboratorio de Neurobiología del Sueño, Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Behav Brain Res ; 476: 115231, 2024 Aug 30.
Article en En | MEDLINE | ID: mdl-39218075
ABSTRACT
Ketamine is an NMDA receptor antagonist that has antidepressant and anesthetic properties. At subanesthetic doses, ketamine induces transient psychosis in humans, and is used to model psychosis in experimental animals. In rodents, subanesthetic doses of ketamine increase the power of high-frequency oscillations (HFO, > 100 Hz) in the electroencephalogram (EEG), a frequency band linked to cognitive functions. However, to date, the effects of ketamine in carnivores and primates have been poorly investigated. Here, we examined in the cat, cortical HFO during wakefulness, sleep, and after administering a sub-anesthetic dose of ketamine. Four cats were prepared with cortical electrodes for chronic polysomnographic recordings in head-restrained conditions. The cortical HFO power, connectivity, direction of the information flow using Granger Causality (GC) analysis, their relationships with respiratory activity, and the effect of auditory stimulation were analyzed. During wakefulness, but not during sleep, we found that HFO were coupled with the inspiratory phase of the respiration. After ketamine administration, HFO power was enhanced and remained associated with the inspiratory phase. GC analysis suggests that ketamine-enhanced HFO originate from the olfactory bulb (OB) and stream towards the prefrontal cortex (Pf). Accordingly, occluding the nostrils significantly reduced the power of the ketamine-enhanced HFO in both the OB and Pf. Finally, auditory stimulation did not affect HFO. In conclusion, the HFO are associated with respiration during wakefulness, but not during sleep. The enhancement of this rhythm by ketamine may disrupt cortical information processing, which could contribute to some of the neuropsychiatric effects associated with ketamine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Behav Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Behav Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos