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Single preoperative radiation therapy with delayed surgery for low-risk breast cancer: Oncologic outcome, toxicity and cosmesis of the SPORT-DS phase I trial.
Lavigne, Danny; Hijal, Tarek; Vavassis, Peter; Guilbert, Marie-Christine; Sideris, Lucas; Dubé, Pierre; Gervais, Mai-Kim; Leblanc, Guy; Dufresne, Michel-Pierre; Nguyen, David; Tiberi, David; Mahmoud, Dima; Yassa, Michael.
Afiliación
  • Lavigne D; Department of Radiation Oncology, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Hijal T; Division of Radiation Oncology, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
  • Vavassis P; Department of Radiation Oncology, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Guilbert MC; Department of Pathology, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Sideris L; Department of Surgery, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Dubé P; Department of Surgery, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Gervais MK; Department of Surgery, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Leblanc G; Department of Surgery, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Dufresne MP; Department of Radiology, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Nguyen D; Department of Radiation Oncology, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada.
  • Tiberi D; Department of Radiation Oncology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
  • Mahmoud D; Division of Radiation Oncology, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
  • Yassa M; Department of Radiation Oncology, HMR - Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada. Electronic address: michael.yassa.med@ssss.gouv.qc.ca.
Radiother Oncol ; 200: 110515, 2024 Aug 30.
Article en En | MEDLINE | ID: mdl-39218041
ABSTRACT

BACKGROUND:

A novel approach using single-fraction preoperative partial breast irradiation (PBI) for low-risk breast cancer is under study. We sought to investigate the rate of pathologic response (pR), toxicities and cosmetic results related to this new treatment strategy.

METHODS:

Women of 65 years or older with stage I unifocal luminal A breast cancer were eligible for inclusion in this phase I prospective trial. Patients received a single 20 Gy dose of PBI followed by breast-conserving surgery (BCS) 3 months later. The primary endpoint was the pR rate, and the secondary endpoints were radiation therapy-related toxicity and cosmetic results.

RESULTS:

Thirteen patients were treated, with a median age of 71. Eleven patients (84.6 %) had pR with a median residual cellularity of 1 % (range 0-10 %). At median follow-up of 48.5 months, no recurrences or cancer-related deaths were recorded. Acute radiation therapy-related toxicity were limited to grade 1 dermatitis and breast pain. At the 1-year follow-up, there were one grade 2 fat necrosis and two grade 3 toxicities (wound infection and hematoma). Only grade 1 toxicities remained at 2 years, but one grade 2 toxicity (fibrosis/induration) developed by the 3-year follow-up. Three-year patient-reported cosmetic outcomes were good or excellent in 60 % of patients.

CONCLUSIONS:

Single-fraction preoperative PBI preceding BCS for low-risk breast cancer is feasible, relatively well tolerated and leads to a high level of pR. The 3-month interval after PBI seems to place surgery in a post-radiation inflammatory phase. Further delay between PBI and surgery could improve pR and cosmetic outcome. NCT03917498.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Radiother Oncol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Radiother Oncol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Irlanda