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High adsorption capacity of hemoperfusion on imipenem in critically ill patients with septic shock: a case report.
Wang, Chuhui; Li, Chao; Yang, Ping; Liu, Kaixi; Xiong, Xin; Liu, Yangang; Li, Xiaoxiao; Zhai, Suodi.
Afiliación
  • Wang C; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China.
  • Li C; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Yang P; Department of Intensive Care Unit, Peking University Third Hospital, Beijing, 100191, China.
  • Liu K; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China.
  • Xiong X; Department of Anesthesiology, Peking University Third Hospital, Beijing, 100191, China.
  • Liu Y; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China.
  • Li X; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
  • Zhai S; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China. lxxsunshine@sina.com.
BMC Infect Dis ; 24(1): 894, 2024 Aug 31.
Article en En | MEDLINE | ID: mdl-39217309
ABSTRACT

BACKGROUND:

Sepsis is a life-threatening organ dysfunction caused by an excessive host response to infection, manifested by elevated levels of inflammatory cytokines. At present, the use of hemoperfusion to remove inflammatory cytokines from the bloodstream has been expanding. Meanwhile, the pharmacokinetics and pharmacodynamics characteristics of antibiotics in critically ill patients may be impacted by hemoperfusion. CASE PRESENTATION The patient was a 69-year-old male with poorly controlled type 2 diabetes. When admitted to the ICU, Multiple Organ Dysfunction Syndrome (MODS) appeared within 48 h, and he was suspected of septic shock due to acute granulocytopenia and significantly increased procalcitonin. Broad-spectrum antibiotics imipenem was administered according to Sepsis 3.0 bundle and hemoperfusion lasting 4 h with a neutron-macroporous resin device (HA-380, Jafron, China) five times was conducted to lower the extremely high value of serum inflammatory factors. Blood samples were collected to measure imipenem plasma concentration to investigate the effect of hemoperfusion quantitatively. This study showed that 4 h of hemoperfusion had a good adsorption ability on inflammatory factors and could remove about 75.2% of imipenem.

CONCLUSIONS:

This case demonstrated the high adsorption capacity of hemoperfusion on imipenem in critically ill patients. It implies a timely imipenem supplement is required, especially before hemoperfusion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Séptico / Imipenem / Hemoperfusión / Enfermedad Crítica / Antibacterianos Límite: Aged / Humans / Male Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Séptico / Imipenem / Hemoperfusión / Enfermedad Crítica / Antibacterianos Límite: Aged / Humans / Male Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido