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Biogenically synthesized green silver nanoparticles exhibit antimalarial activity.
Tiwari, Savitri; Kumar, Reetesh; Devi, Sonia; Sharma, Prakriti; Chaudhary, Neil Roy; Negi, Sushmita; Tandel, Nikunj; Marepally, Srujan; Pied, Sylviane; Tyagi, Rajeev K.
Afiliación
  • Tiwari S; School of Biological and Life Sciences, Galgotias University, Gautam Buddha Nagar, Greater Noida, 201310, India.
  • Kumar R; Faculty of Agricultural Sciences, Institute of Applied Sciences and Humanities, GLA University, Mathura, 281406, India.
  • Devi S; Biomedical Parasitology and Translational-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India.
  • Sharma P; Academy of Scientific and Innovation Research (AcSIR), Ghaziabad, 201002, India.
  • Chaudhary NR; Biomedical Parasitology and Translational-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India.
  • Negi S; Biomedical Parasitology and Translational-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India.
  • Tandel N; Biomedical Parasitology and Translational-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India.
  • Marepally S; Academy of Scientific and Innovation Research (AcSIR), Ghaziabad, 201002, India.
  • Pied S; Institute of Science, Nirma University, Ahmedabad, Gujarat, India.
  • Tyagi RK; Malaria Research Lab, CSIR-Centre for Cellular and Molecular Biology (CCMB), Habsiguda, Hyderabad, Telangana, 500007, India.
Discov Nano ; 19(1): 136, 2024 Aug 31.
Article en En | MEDLINE | ID: mdl-39217276
ABSTRACT
The suboptimal efficacies of existing anti-malarial drugs attributed to the emergence of drug resistance dampen the clinical outcomes. Hence, there is a need for developing novel drug and drug targets. Recently silver nanoparticles (AgNPs) constructed with the leaf extracts of Euphorbia cotinifolia were shown to possess antimalarial activity. Therefore, the synthesized AgNPs from Euphorbia cotinifolia (EcAgNPs) were tested for their parasite clearance activity. We determined the antimalarial activity in the asexual blood stage infection of 3D7 (laboratory strain) P. falciparum. EcAgNPs demonstrated the significant inhibition of parasite growth (EC50 of 0.75 µg/ml) in the routine in vitro culture of P. falciparum. The synthesized silver nanoparticles were seen to induce apoptosis in P. falciparum through increased reactive oxygen species (ROS) ROS production and activated programmed cell death pathways characterized by the caspase-3 and calpain activity. Also, altered transcriptional regulation of Bax/Bcl-2 ratio indicated the enhanced apoptosis. Moreover, inhibited expression of PfLPL-1 by EcAgNPs is suggestive of the dysregulated host fatty acid flux via parasite lipid storage. Overall, our findings suggest that EcAgNPs are a non-toxic and targeted antimalarial treatment, and could be a promising therapeutic approach for clearing malaria infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Discov Nano Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Discov Nano Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza