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Depression and the risk of non-alcohol fatty liver disease: Results from a cross-sectional study and a Mendelian randomization analysis.
Lv, Duoduo; Han, Ning; Yuan, Man; Huang, Wei; Yan, Libo; Tang, Hong.
Afiliación
  • Lv D; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province 610041, China.
  • Han N; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province 610041, China.
  • Yuan M; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
  • Huang W; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province 610041, China.
  • Yan L; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province 610041, China. Electronic address: yanlibo@wchscu.cn.
  • Tang H; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province 610041, China. Electronic address: tanghong6198@wchscu.cn.
J Affect Disord ; 366: 300-307, 2024 Dec 01.
Article en En | MEDLINE | ID: mdl-39216642
ABSTRACT

BACKGROUND:

Previous studies have suggested that psychiatric factors may be pathogenic for NAFLD. However, the association between depression and NAFLD is not been consistent, and whether depression plays a causal role in the development of NAFLD remains unclear.

METHODS:

We extracted data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 to assess the correlation between depression and NAFLD risk. Based on previous genome-wide association studies (GWAS) meta-analyses on NAFLD and depression, we performed a Mendelian randomization (MR) analysis to explore the causal effect of depression on NAFLD. The primary analysis method used in the MR analysis was inverse variance weighted.

RESULTS:

We ultimately extracted the data from 3878 individuals in the NHANES database to perform the cross-sectional study. Multivariable-adjusted logistic regression showed that depressed individuals had a higher risk of NAFLD than controls (odds ratio [OR] 1.33, 95 % CI 1.03-1.72, p = 0.027) among women. Based on GWAS data, we included 36 genetic variants as instrumental variables to estimate the causal effect of depression on NAFLD risk. The MR analysis revealed a causal association between genetically predicted depression and an increased risk of NAFLD (OR = 1.504, 95 % CI 1.13-2.00, p = 0.005).

LIMITATIONS:

The consistency of these findings in Eastern populations requires further longitudinal studies.

CONCLUSIONS:

This cross-sectional study suggested that depression might increase the risk of NAFLD in women. The MR analysis demonstrated that there exists a causal association between genetically predicated depression and NAFLD risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depresión / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Enfermedad del Hígado Graso no Alcohólico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depresión / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Enfermedad del Hígado Graso no Alcohólico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos