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An international consensus on the use of asthma biologics in pregnancy.
Naftel, Jennifer; Jackson, David J; Coleman, Matthew; d'Ancona, Grainne; Heaney, Liam G; Dennison, Paddy; Bossios, Apostolos; Rupani, Hitasha.
Afiliación
  • Naftel J; National Institute for Health Research Southampton Biomedical Research Centre and Department of Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Jackson DJ; School of Immunology and Microbial Sciences, King's College London, London, UK; Guy's Severe Asthma Centre, Guy's and St Thomas' NHS Foundation Trust Hospital, London, UK.
  • Coleman M; Department of Maternal and Foetal Medicine, Princess Anne Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • d'Ancona G; Guy's Severe Asthma Centre, Guy's and St Thomas' NHS Foundation Trust Hospital, London, UK.
  • Heaney LG; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
  • Dennison P; National Institute for Health Research Southampton Biomedical Research Centre and Department of Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Bossios A; Karolinska Severe Asthma Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden; Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
  • Rupani H; National Institute for Health Research Southampton Biomedical Research Centre and Department of Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Clinical and Experimental Sciences, School of Medicine, University of Southampton, Southampton, UK. Electronic
Lancet Respir Med ; 2024 Aug 28.
Article en En | MEDLINE | ID: mdl-39216499
ABSTRACT
Uncontrolled asthma is associated with an increased risk of adverse perinatal outcomes. Asthma biologics reduce exacerbation frequency, are steroid sparing, and improve quality of life in people with severe asthma. However, evidence for the use and safety of asthma biologics during pregnancy is scarce, largely because pregnant women were excluded from clinical trials. To help to support clinical teams, we conducted an international modified Delphi study. 141 panellists from 32 countries who were involved in the care of people with severe asthma completed two rounds of online surveys covering key areas surrounding the use of asthma biologics in pregnancy. The results from this international Delphi study emphasise risk versus benefit discussions and shared clinical decision making, with consensus among panellists that asthma biologics can be used during conception and throughout pregnancy, initiated during pregnancy in line with prescribing criteria for non-pregnant people, and initiated or continued during breastfeeding. Collating data through international registries remains essential to inform clinical guidelines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Lancet Respir Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Lancet Respir Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido