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The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis.
Ran, Ling; Yue, Zhengliang; Ran, Mengqu; Liu, Qiao; Su, Xingxing; Wang, Lisha; Wen, Shuqiong; Xu, Luming; Lei, Shun; Ou, Zhanpeng; Hu, Jianjun; Zhang, Yan; Qin, Chenxi; Wang, Yuzhu; He, Qinyi; Chen, Yezi; Liu, Wen; Ye, Lilin; Huang, Qizhao; Xu, Lifan.
Afiliación
  • Ran L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Yue Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Ran M; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China.
  • Liu Q; Division of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Su X; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wang L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wen S; Stomatological Hospital of Chongqing Medical University, Chongqing, China.
  • Xu L; Medical Laboratory Technology, Southern Medical University, Guangzhou, China.
  • Lei S; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Ou Z; Stomatological Hospital of Chongqing Medical University, Chongqing, China.
  • Hu J; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Zhang Y; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), Chongqing Medical University, Chongqing, China.
  • Qin C; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wang Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • He Q; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Chen Y; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China.
  • Liu W; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China.
  • Ye L; Institute of Immunology, Third Military Medical University, Chongqing, China. Electronic address: yelilinlcmv@tmmu.edu.cn.
  • Huang Q; Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China. Electronic address: huangqizhao1988@163.com.
  • Xu L; Institute of Immunology, Third Military Medical University, Chongqing, China. Electronic address: xlftofu@tmmu.edu.cn.
Cell Rep ; 43(9): 114690, 2024 Sep 24.
Article en En | MEDLINE | ID: mdl-39216001
ABSTRACT
During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-TTSM cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (TPEX) cells and further replenishes tumor-specific CD8+ T cells residing in the tumor microenvironment (TME). However, how TTSM cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by TTSM cells compared with other CD8+ T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of TTSM and TPEX cells, resulting in decreased tumor-infiltrating CD8+ T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8+ T cells increases the TTSM cell population and enhances the anti-tumor immune response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD8-positivos / Proteínas Inhibidoras de la Diferenciación / Carcinogénesis / Ganglios Linfáticos / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD8-positivos / Proteínas Inhibidoras de la Diferenciación / Carcinogénesis / Ganglios Linfáticos / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos