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The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study.
Khor, Wei-Boon; Lakshminarayanan, Rajamani; Periayah, Mercy Halleluyah; Prajna, Venkatesh N; Garg, Prashant; Sharma, Namrata; Mehta, Jodhbir S; Young, Alvin; Goseyarakwong, Panida; Puangsricharern, Vilavun; Tan, Ai Ling; Beuerman, Roger W; Tan, Donald Tiang-Hwee.
Afiliación
  • Khor WB; Singapore National Eye Centre, Singapore, Singapore.
  • Lakshminarayanan R; Singapore Eye Research Institute, Singapore, Singapore.
  • Periayah MH; Duke-NUS Graduate Medical School, Singapore, Singapore.
  • Prajna VN; Singapore Eye Research Institute, Singapore, Singapore.
  • Garg P; Duke-NUS Graduate Medical School, Singapore, Singapore.
  • Sharma N; Department of Pharmacy, National University of Singapore, Singapore, Singapore.
  • Mehta JS; Singapore Eye Research Institute, Singapore, Singapore.
  • Young A; Aravind Eye Care System, Madurai, Tamil Nadu, India.
  • Goseyarakwong P; LV Prasad Eye Institute, Hyderabad, Telangana, India.
  • Puangsricharern V; Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
  • Tan AL; Singapore National Eye Centre, Singapore, Singapore.
  • Beuerman RW; Singapore Eye Research Institute, Singapore, Singapore.
  • Tan DT; Duke-NUS Graduate Medical School, Singapore, Singapore.
Int Ophthalmol ; 44(1): 361, 2024 Aug 31.
Article en En | MEDLINE | ID: mdl-39215853
ABSTRACT

PURPOSE:

To describe the prevalence and antibiotic resistance profiles of Pseudomonas aeruginosa isolated from the Asia Cornea Society Infectious Keratitis Study (ACSIKS).

METHODS:

All bacterial isolates from ACSIKS underwent repeat microbiological identification in a central repository in Singapore. Minimum inhibitory concentration (MIC) determination was conducted for isolates of P. aeruginosa against thirteen antibiotics from 6 different classes, and categorized based on Clinical Laboratory Standard Institutes' reference ranges. The percentage rates of resistance (non-susceptibility) to each antibiotic included isolates of both intermediate and complete resistance. Multi-drug resistance (MDR) was defined as non-susceptibility to at least one agent in three or more antimicrobial classes.

RESULTS:

Of the 1493 unique bacterial specimens obtained from ACSIKS, 319 isolates were of P. aeruginosa. The majority of isolates were from centers in India (n = 118, 37%), Singapore (n = 90, 28.2%), Hong Kong (n = 31, 9.7%) and Thailand (n = 30, 9.4%). The cumulative antibiotic resistance rate was the greatest for polymyxin B (100%), ciprofloxacin (17.6%) and moxifloxacin (16.9%), and lowest for cefepime (11.6%) and amikacin (13.5%). Isolates from India demonstrated the highest antibiotic resistance rates of all the centers, and included moxifloxacin (47.5%) and ciprofloxacin (39.8%). Forty-eight of the 59 MDR isolates also originated from India. Antibiotic resistance rates were significantly lower in the other ACSIKS centers, and were typically less than 10%.

CONCLUSIONS:

The antibiotic resistance profiles of P. aeruginosa varied between different countries. While it was low for most countries, substantial antibiotic resistance and a significant number of multi-drug resistant isolates were noted in the centers from India.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas / Pruebas de Sensibilidad Microbiana / Infecciones Bacterianas del Ojo / Antibacterianos Límite: Female / Humans / Male Idioma: En Revista: Int Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas / Pruebas de Sensibilidad Microbiana / Infecciones Bacterianas del Ojo / Antibacterianos Límite: Female / Humans / Male Idioma: En Revista: Int Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos