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Assessing hip joint-related structure and patient-reported outcomes in people with Marfan syndrome.
Cochran, Kylie E; Steele, Lucas T; Fain, Aaron D; Gaffney, Brecca M M; McLouth, Christopher J; Sheppard, Mary B; Samaan, Michael A.
Afiliación
  • Cochran KE; College of Medicine, University of Kentucky, Lexington, KY, USA.
  • Steele LT; College of Medicine, University of Kentucky, Lexington, KY, USA.
  • Fain AD; Department of Radiology, University of Kentucky, Lexington, KY, USA.
  • Gaffney BMM; Department of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA.
  • McLouth CJ; Center for Bioengineering, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Sheppard MB; Department of Veterans Affairs Eastern Colorado Healthcare System, Aurora, CO, USA.
  • Samaan MA; Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
Skeletal Radiol ; 2024 Aug 31.
Article en En | MEDLINE | ID: mdl-39215835
ABSTRACT

OBJECTIVE:

People with Marfan syndrome (MFS) have clinical symptoms of hip pain, but to date, there is limited knowledge about hip-related structural abnormalities in these patients. Therefore, the purpose of this cross-sectional study was to assess hip-related structural abnormalities and patient-reported outcomes (PRO) in a cohort of patients with MFS compared to healthy controls.

METHODS:

Nineteen individuals with MFS (17 females, 39.8±11.5 years) and 19 age, sex, and body mass index-matched healthy, asymptomatic individuals (17 females, 36.2±12.5 years) underwent radiographic imaging and unilateral hip MRI. The Scoring Osteoarthritis with MRI (SHOMRI) technique was used to assess hip-related morphological abnormalities between the MFS and control groups. All participants completed the Hip disability and Osteoarthritis Outcome Score (HOOS) to assess hip-related symptoms, pain, and function during activities of daily living (ADL) and quality of life (QOL).

RESULTS:

The MFS group exhibited higher lateral center edge angles (p < .001). Despite similar severity of femoral cartilage damage (p = 1.0), the MFS group exhibited a higher severity (p = 0.046) of acetabular cartilage degeneration (1.21±1.08) compared to the controls (0.53±1.02). There were no between-group differences in severity of labral pathology, subchondral cysts, or edema. Individuals with MFS also self-reported significantly lower HOOS symptoms (p = 0.003), pain (p = 0.014), ADL (p = 0.028), and QOL (p = 0.014) sub-scores, indicating worse hip-related PRO in MFS.

CONCLUSION:

Our study results suggest that individuals with MFS exhibit early signs of acetabular cartilage degeneration and poor hip-related clinical outcomes compared to healthy individuals. Future work should investigate the underlying biomechanical mechanisms associated with hip joint degeneration in the MFS population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Skeletal Radiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Skeletal Radiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania