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Use of a decision support tool and quick start onboarding tool in individuals with type 1 diabetes using advanced automated insulin delivery: a single-arm multi-phase intervention study.
Sehgal, Shekhar; De Bock, Martin; Grosman, Benyamin; Williman, Jonathan; Kurtz, Natalie; Guzman, Vanessa; Benedetti, Andrea; Roy, Anirban; Turksoy, Kamuran; Juarez, Magaly; Jones, Shirley; Frewen, Carla; Watson, Antony; Taylor, Barry; Wheeler, Benjamin J.
Afiliación
  • Sehgal S; Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, 201 Great King St, Dunedin, Otago, 9016, New Zealand.
  • De Bock M; Department of Endocrinology and Diabetes, North Shore Hospital, Te Whatu Ora Waitemata , Auckland, New Zealand.
  • Grosman B; Department of Paediatrics, Te Whatu Ora Waitaha, Christchurch, New Zealand.
  • Williman J; Department of Paediatrics, University of Otago, Christchurch, New Zealand.
  • Kurtz N; Medtronic Inc, Northeast Minneapolis, 710 Medtronic Parkway, Minneapolis, MN, USA.
  • Guzman V; Department of Paediatrics, Te Whatu Ora Waitaha, Christchurch, New Zealand.
  • Benedetti A; Medtronic Inc, Northeast Minneapolis, 710 Medtronic Parkway, Minneapolis, MN, USA.
  • Roy A; Medtronic Inc, Northeast Minneapolis, 710 Medtronic Parkway, Minneapolis, MN, USA.
  • Turksoy K; Medtronic Inc, Northeast Minneapolis, 710 Medtronic Parkway, Minneapolis, MN, USA.
  • Juarez M; Medtronic Inc, Northeast Minneapolis, 710 Medtronic Parkway, Minneapolis, MN, USA.
  • Jones S; Medtronic Inc, Northeast Minneapolis, 710 Medtronic Parkway, Minneapolis, MN, USA.
  • Frewen C; Medtronic Inc, Northeast Minneapolis, 710 Medtronic Parkway, Minneapolis, MN, USA.
  • Watson A; Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, 201 Great King St, Dunedin, Otago, 9016, New Zealand.
  • Taylor B; Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, 201 Great King St, Dunedin, Otago, 9016, New Zealand.
  • Wheeler BJ; Department of Paediatrics, Te Whatu Ora Waitaha, Christchurch, New Zealand.
BMC Endocr Disord ; 24(1): 167, 2024 Aug 30.
Article en En | MEDLINE | ID: mdl-39215272
ABSTRACT

BACKGROUND:

Multiple clinician adjustable parameters impact upon glycemia in people with type 1 diabetes (T1D) using Medtronic Mini Med 780G (MM780G) AHCL. These include glucose targets, carbohydrate ratios (CR), and active insulin time (AIT). Algorithm-based decision support advising upon potential settings adjustments may enhance clinical decision-making.

METHODS:

Single-arm, two-phase exploratory study developing decision support to commence and sustain AHCL. Participants commenced investigational MM780G, then 8 weeks Phase 1-initial optimization tool evaluation, involving algorithm-based decision support with weekly AIT and CR recommendations. Clinicians approved or rejected CR and AIT recommendations based on perceived safety per protocol. Co-design resulted in a refined algorithm evaluated in a further identically configured Phase 2. Phase 2 participants also transitioned to commercial MM780G following "Quick Start" (algorithm-derived tool determining initial AHCL settings using daily insulin dose and weight). We assessed efficacy, safety, and acceptability of decision support using glycemic metrics, and the proportion of accepted CR and AIT settings per phase.

RESULTS:

Fifty three participants commenced Phase 1 (mean age 24.4; Hba1c 61.5mmol/7.7%). The proportion of CR and AIT accepted by clinicians increased between Phases 1 and 2 respectively CR 89.2% vs. 98.6%, p < 0.01; AIT 95.2% vs. 99.3%, p < 0.01. Between Phases, mean glucose percentage time < 3.9mmol (< 70mg/dl) reduced (2.1% vs. 1.4%, p = 0.04); change in mean TIR 3.9-10mmol/L (70-180mg/dl) was not statistically significant 72.9% ± 7.8 and 73.5% ± 8.6. Quick start resulted in stable TIR, and glycemic metrics compared to international guidelines.

CONCLUSION:

The co-designed decision support tools were able to deliver safe and effective therapy. They can potentially reduce the burden of diabetes management related decision making for both health care practitioners and patients. TRIAL REGISTRATION Prospectively registered with Australia/New Zealand Clinical Trials Registry(ANZCTR) on 30th March 2021 as study ACTRN12621000360819.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Sistemas de Infusión de Insulina / Diabetes Mellitus Tipo 1 / Hipoglucemiantes / Insulina Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: BMC Endocr Disord Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Sistemas de Infusión de Insulina / Diabetes Mellitus Tipo 1 / Hipoglucemiantes / Insulina Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: BMC Endocr Disord Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido