Your browser doesn't support javascript.
loading
Feasibility and safety of surfactant administration via laryngeal mask airway as first-line therapy for a select newborn population: results of a standardized clinical protocol.
Kubicka, Zuzanna; Zahr, Eyad; Feldman, Henry A; Rousseau, Tamara; Welgs, Theresa; Ditzel, Amy; Perry, Diana; Lacy, Molly; O'Rourke, Carolyn; Arzuaga, Bonnie.
Afiliación
  • Kubicka Z; Department of Pediatrics, South Shore Hospital, Weymouth, MA, USA. zkubicka5@gmail.com.
  • Zahr E; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA. zkubicka5@gmail.com.
  • Feldman HA; Harvard Medical School, Boston, MA, USA. zkubicka5@gmail.com.
  • Rousseau T; Department of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
  • Welgs T; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Ditzel A; Harvard Medical School, Boston, MA, USA.
  • Perry D; Institutional Centers for Clinical and Translational Studies, Boston Children's Hospital, Boston, MA, USA.
  • Lacy M; Department of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
  • O'Rourke C; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Arzuaga B; Department of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
J Perinatol ; 2024 Aug 30.
Article en En | MEDLINE | ID: mdl-39215195
ABSTRACT

OBJECTIVES:

(1) To demonstrate feasibility and safety of surfactant administration via laryngeal mask airway (LMA) as a first-line therapy. (2) To measure treatment success, defined as avoidance of intubation/invasive mechanical ventilation, and determine if specific clinical variables could predict success/failure. STUDY

DESIGN:

Observational cohort with eligible infants given surfactant using one type of LMA via standardized protocol. Data was captured prospectively followed by retrospective chart review.

RESULTS:

120 infants ≥1250 g and 28.3-41.1 weeks gestation were included. First-line LMA surfactant therapy was successful in 70% of the infants and those infants weaned to room air significantly quicker than infants requiring subsequent intubation/mechanical ventilation (p = 0.002 by 72 h, p = 0.001 by 96 h). Clinical variables assessed could not predict treatment success/failure. Complications were infrequent and did not differ between groups.

CONCLUSION:

First-line LMA surfactant is feasible and safe for certain infants. Prediction of treatment success was not possible in our cohort.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos