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Peptidomic profile of human milk as influenced by fortification with different protein sources: An in vitro dynamic digestion simulation.
Giribaldi, Marzia; Nebbia, Stefano; Briard-Bion, Valerie; Jardin, Julien; Ménard, Olivia; Dupont, Didier; Coscia, Alessandra; Cresi, Francesco; Lamberti, Cristina; Cavallarin, Laura; Deglaire, Amélie.
Afiliación
  • Giribaldi M; CNR Institute of Sciences of Food Production, Largo Braccini 2, 10095 Grugliasco, TO, Italy. Electronic address: marzia.giribaldi@cnr.it.
  • Nebbia S; CNR Institute of Sciences of Food Production, Largo Braccini 2, 10095 Grugliasco, TO, Italy; INRAE, L'Institut Agro, Science et Technologie du Lait et de l'Oeuf, 65 Rue de St Brieuc, 35042 Rennes, France.
  • Briard-Bion V; INRAE, L'Institut Agro, Science et Technologie du Lait et de l'Oeuf, 65 Rue de St Brieuc, 35042 Rennes, France. Electronic address: valerie.briard-bion@inrae.fr.
  • Jardin J; INRAE, L'Institut Agro, Science et Technologie du Lait et de l'Oeuf, 65 Rue de St Brieuc, 35042 Rennes, France. Electronic address: julien.jardin@inrae.fr.
  • Ménard O; INRAE, L'Institut Agro, Science et Technologie du Lait et de l'Oeuf, 65 Rue de St Brieuc, 35042 Rennes, France. Electronic address: olivia.menard@inrae.fr.
  • Dupont D; INRAE, L'Institut Agro, Science et Technologie du Lait et de l'Oeuf, 65 Rue de St Brieuc, 35042 Rennes, France. Electronic address: dider.dupont@inrae.fr.
  • Coscia A; Neonatal Unit, University of Turin, City of Health and Science of Turin, via Ventimiglia 3, 10126 Turin, Italy. Electronic address: alessandra.coscia@unito.it.
  • Cresi F; Neonatal Unit, University of Turin, City of Health and Science of Turin, via Ventimiglia 3, 10126 Turin, Italy. Electronic address: francesco.cresi@unito.it.
  • Lamberti C; CNR Institute of Sciences of Food Production, Largo Braccini 2, 10095 Grugliasco, TO, Italy. Electronic address: cristina.lambert@cnr.it.
  • Cavallarin L; CNR Institute of Sciences of Food Production, Largo Braccini 2, 10095 Grugliasco, TO, Italy. Electronic address: laura.cavallarin@cnr.it.
  • Deglaire A; INRAE, L'Institut Agro, Science et Technologie du Lait et de l'Oeuf, 65 Rue de St Brieuc, 35042 Rennes, France. Electronic address: amelie.deglaire@institut-agro.fr.
Food Chem ; 462: 140886, 2025 Jan 01.
Article en En | MEDLINE | ID: mdl-39213965
ABSTRACT
Fortification of human milk (HM) is often necessary to meet the nutritional requirements of preterm infants. The present experiment aimed to establish whether the supplementation of HM with either an experimental donkey milk-derived fortifier containing whole donkey milk proteins, or with a commercial bovine milk-derived fortifier containing hydrolyzed bovine whey proteins, affects peptide release differently during digestion. The experiment was conducted using an in vitro dynamic system designed to simulate the preterm infant's digestion followed by digesta analysis by means of LC-MS-MS. The different fortifiers did not appear to influence the cumulative intensity of HM peptides. Fortification had a differential impact on the release of either donkey or bovine bioactive peptides. Donkey milk peptides showed antioxidant/ACE inhibitory activities, while bovine peptides showed opioid, dipeptil- and propyl endo- peptidase inhibitory and antimicrobial activity. A slight delay in peptide release from human lactoferrin and α-lactalbumin was observed when HM was supplemented with donkey milk-derived fortifier.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Equidae / Digestión / Leche Humana / Proteínas de la Leche Límite: Animals / Humans Idioma: En Revista: Food Chem Año: 2025 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Equidae / Digestión / Leche Humana / Proteínas de la Leche Límite: Animals / Humans Idioma: En Revista: Food Chem Año: 2025 Tipo del documento: Article Pais de publicación: Reino Unido