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Exploring blood transcriptomic signatures in patients with herpes zoster and postherpetic neuralgia.
Wang, Chunliang; Zhang, Kaiyi; Bao, Yuhan; Liu, Ye; Zhou, You; Ji, Yong-Hua; Wang, Hongjie; Tan, Zhi-Yong.
Afiliación
  • Wang C; Department of Pain Management, Affiliated Hospital of Hebei University/School of Clinical Medicine, Hebei University, Baoding, Hebei, China.
  • Zhang K; School of Basic Medicine, Hebei University, Baoding, Hebei, China.
  • Bao Y; School of Basic Medicine, Hebei University, Baoding, Hebei, China.
  • Liu Y; School of Basic Medicine, Hebei University, Baoding, Hebei, China.
  • Zhou Y; Department of Anesthesia, Affiliated Hospital of Hebei University/School of Clinical Medicine, Hebei University, Baoding, Hebei, China.
  • Ji YH; School of Basic Medicine, Hebei University, Baoding, Hebei, China.
  • Wang H; School of Basic Medicine, Hebei University, Baoding, Hebei, China.
  • Tan ZY; School of Basic Medicine, Hebei University, Baoding, Hebei, China.
Front Cell Infect Microbiol ; 14: 1425393, 2024.
Article en En | MEDLINE | ID: mdl-39211798
ABSTRACT
Postherpetic neuralgia (PHN) is a common, severe, and hard-to-treat chronic pain condition in clinics. Although PHN is developed from herpes zoster (HZ), the developing mechanism is unknown. A previous study investigated blood metabolomic and proteomic profiling in patients with PHN and HZ. The current study aims to explore the blood transcriptomic signature of PHN compared to HZ patients. Whole blood from eight PHN and 15 HZ patients was used for RNA-Seq analysis. There were 82 and 1,788 genes detected specifically in the PHN and HZ groups, respectively. PHN-specific genes are involved in viral infection, lipid and carbohydrate metabolism, and immune response. For genes coexpressed in PHN and HZ patients, there were 407 differential expression genes (DEGs), including 205 upregulated (UP DEGs) and 202 downregulated (DOWN DEGs) in PHN compared to HZ groups. DEGs are involved in viral infection, type I interferon (IFN), and hemoglobin and oxygen carrier activity. UP DEGs are associated with regulatory T cells (Tregs), activated NK cells, and neutrophils, while DOWN DEGs are associated with Tregs, resting NK cells, and monocytes. The results suggest that the metabolism of lipid, glycan, and nucleotides, type I IFN signaling, and altered neutrophil activation are associated with and might contribute to the development of PHN in HZ. It is also suggested that persistent or altered activation of nonspecific immunity may contribute to the development of PHN from HZ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perfilación de la Expresión Génica / Neuralgia Posherpética / Transcriptoma / Herpes Zóster Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Cell Infect Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perfilación de la Expresión Génica / Neuralgia Posherpética / Transcriptoma / Herpes Zóster Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Cell Infect Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza