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Case Report: Tropical sprue, diagnostic challenges of an old but unrecognized disease.
Guissouma, Jihene; Ben Ali, Hana; Allouche, Hend; Trabelsi, Insaf; Hammami, Olfa; Yahia, Yosra; Mchirgui, Ilhem; Mabrouk, Marwa; Ghadhoune, Hatem.
Afiliación
  • Guissouma J; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, 1007, Tunisia.
  • Ben Ali H; Medical intensive care unit, Habib Bougatfa university hospital, Bizerte, 7021, Tunisia.
  • Allouche H; Medical intensive care unit, Habib Bougatfa university hospital, Bizerte, 7021, Tunisia.
  • Trabelsi I; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, 1007, Tunisia.
  • Hammami O; Medical intensive care unit, Habib Bougatfa university hospital, Bizerte, 7021, Tunisia.
  • Yahia Y; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, 1007, Tunisia.
  • Mchirgui I; Medical intensive care unit, Habib Bougatfa university hospital, Bizerte, 7021, Tunisia.
  • Mabrouk M; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, 1007, Tunisia.
  • Ghadhoune H; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, 1007, Tunisia.
F1000Res ; 11: 1206, 2022.
Article en En | MEDLINE | ID: mdl-39211424
ABSTRACT
Tropical sprue (TS) is a post-infective disease of the small bowel characterized by a malabsorption syndrome affecting tropics inhabitants and visitors. Diagnosis of TS remains challenging since it can be confused with common diarrheal diseases, especially in non-endemic areas. We report a Tunisian case of latent TS. A 58-year-old male with a history of chronic watery diarrhea, was admitted to the intensive care unit for confusion which was related to a severe metabolic acidosis. Despite the neurological improvement after hydro-electrolytic resuscitation and acid-base disorders correction, the patient continued to have three to five loose stools daily. A nutritional assessment showed a malabsorption syndrome iron, Vitamin B12and folate deficiencies; normochromic normocytic anemia and hypoalbuminemia. Gastrointestinal endoscopy showed duodenal villous atrophy and biopsy confirmed subtotal villous atrophy with increased intraepithelial lymphocytosis and a thickened hyalonalized sub-epithelial basal lamina. Celiac disease was evoked, however the patient did not improve on a gluten-free diet and the celiac serology was negative. On re-interviewing, we discovered that the patient had spent two months in India three years prior. Given the travel history, clinico-biological and histological data TS was highly considered and a good response to a five-month antibiotic course combined to nutritional supplementation supported this diagnosis. Clinico-biological, endoscopic and histological findings were overlapping between TS and other malabsorption diseases, explaining diagnosis difficulties. TS should be systematically discussed in tropics visitors presenting with chronic diarrhea. Improvement after micronutrient and vitamin deficiencies replacement combined to a prolonged antibiotic course supports the diagnosis of TS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esprue Tropical Límite: Humans / Male / Middle aged Idioma: En Revista: F1000Res Año: 2022 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esprue Tropical Límite: Humans / Male / Middle aged Idioma: En Revista: F1000Res Año: 2022 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido