Your browser doesn't support javascript.
loading
Unveiling the potential role of micro/nano biomaterials in the treatment of Helicobacter pylori infection.
Fathi Kisomi, Misagh; Yadegar, Abbas; Shekari, Tara; Amin, Mohsen; Llopis-Lorente, Antoni; Liu, Chenguang; Haririan, Ismaeil; Aghdaei, Hamid Asadzadeh; Shokrgozar, Mohammad Ali; Zali, Mohammad Reza; Rad-Malekshahi, Mazda; Miri, Amir Hossein; Hamblin, Michael R; Wacker, Matthias G.
Afiliación
  • Fathi Kisomi M; Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Yadegar A; Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Shekari T; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Amin M; Department of Drug and Food Control, Faculty of Pharmacy, and the Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
  • Llopis-Lorente A; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Valencia, Spain.
  • Liu C; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain.
  • Haririan I; College of Marine Life Science, Ocean University of China, Qingdao, P.R. China.
  • Aghdaei HA; Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Shokrgozar MA; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Zali MR; National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
  • Rad-Malekshahi M; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Miri AH; Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Hamblin MR; Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Wacker MG; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa.
Expert Rev Anti Infect Ther ; 22(8): 613-630, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39210553
ABSTRACT

INTRODUCTION:

Helicobacter pylori causes stubborn infections and leads to a variety of stomach disorders, such as peptic ulcer, chronic atrophic gastritis, and gastric cancer. Although antibiotic-based approaches have been widely used against H. pylori, some challenges such as antibiotic resistance are increasing in severity. Therefore, simpler but more effective strategies are needed. AREAS COVERED In this review, basic information on functionalized and non-functionalized micro/nano biomaterials and routes of administration for H. pylori inhibition are provided in an easy-to-understand format. Afterward, in vitro and in vivo studies of some promising bio-platforms including metal-based biomaterials, biopolymers, small-molecule saccharides, and vaccines for H. pylori inhibition are discussed in a holistic manner. EXPERT OPINION Functionalized or non-functionalized micro/nano biomaterials loaded with anti-H. pylori agents can show efficient bactericidal activity with no/slight negative influence on the host gastrointestinal microbiota. However, this claim needs to be substantiated with hard data such as assessment of the biopharmaceutical parameters of anti-H. pylori systems and the measurement of diversity/abundance of bacterial genera in the host gastric/gut microbiota before and after H. pylori eradication.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Helicobacter pylori / Infecciones por Helicobacter / Antibacterianos Límite: Animals / Humans Idioma: En Revista: Expert Rev Anti Infect Ther Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Helicobacter pylori / Infecciones por Helicobacter / Antibacterianos Límite: Animals / Humans Idioma: En Revista: Expert Rev Anti Infect Ther Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido