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Association of sex with in-hospital management and outcomes of patients with heart failure: data from the REAL-HF registry: The impact of sex in patients hospitalized for heart failure.
Sanna, Giuseppe D; Erre, Gian Luca; Cameli, Matteo; Guerra, Federico; Pastore, Maria Concetta; Marini, Alessandro; Campora, Alessandro; Gironella, Pierpaolo; Costamagna, Mario; Mandoli, Giulia Elena; Casiraghi, Mirko; Scuteri, Angelo; Lisi, Matteo; Casu, Gavino; Deidda, Martino; Dessalvi, Christian Cadeddu.
Afiliación
  • Sanna GD; Clinical and Interventional Cardiology, Sassari University Hospital, Sassari (Italy). Electronic address: giuseppe.sanna@aouss.it.
  • Erre GL; Department of Medicine, Surgery and Pharmacy, University and AOU of Sassari, Sassari (Italy).
  • Cameli M; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena (Italy).
  • Guerra F; Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona (Italy).
  • Pastore MC; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena (Italy).
  • Marini A; Clinical and Interventional Cardiology, Sassari University Hospital, Sassari (Italy).
  • Campora A; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena (Italy).
  • Gironella P; Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona (Italy).
  • Costamagna M; Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona (Italy).
  • Mandoli GE; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena (Italy).
  • Casiraghi M; Clinical and Interventional Cardiology, Sassari University Hospital, Sassari (Italy).
  • Scuteri A; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari (Italy).
  • Lisi M; Department of Cardiovascular Disease, AUSL Romagna, Division of Cardiology, Ravenna (Italy).
  • Casu G; Clinical and Interventional Cardiology, Sassari University Hospital, Sassari (Italy); Department of Medicine, Surgery and Pharmacy, University and AOU of Sassari, Sassari (Italy).
  • Deidda M; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari (Italy).
  • Dessalvi CC; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari (Italy).
Am Heart J ; 2024 Aug 27.
Article en En | MEDLINE | ID: mdl-39209210
ABSTRACT

BACKGROUND:

There are sex differences in HF patients. It is not clear whether such differences mainly reflect cultural behaviours and clinical inertia, and the role of sex on clinical outcomes is still controversial. We aimed to investigate the association of sex with in-hospital management and outcomes in patients with HF.

METHODS:

We analyzed data of 4016 adult patients hospitalized for HF in 2020-2021 and enrolled in a multicentre national registry.

RESULTS:

Women (n=1818[45%]) were older than men (83vs77 years, p<0.0001), with a higher prevalence of arterial hypertension (73%vs69%, p=0.011) and atrial fibrillation. Women presented more frequently with HF and preserved ejection fraction -HFpEF (55%vs32%, p<0.001). They were more often hospitalized in internal medicine departments (71%vs51%), and men in highly specialized cardiology units (49%vs29%). When considering HF pharmacological treatments at discharge in the subgroup with reduced ejection fraction -HFrEF (n=1525), there were no significant differences (49% of women treated with GDMT [guideline-directed medical therapy] vs 52% of men, p=0.197). Sex was not associated either with hospital readmissions (30-days OR[95%CI]=0.89[0.71-1.11], p=0.304; 1-year OR[95%CI]=1.02[0.88-1.19], p=0.777) or with mortality (in-hospital OR[95%CI]=1.14[0.73-1.78], p=0.558; 1-year OR[95%CI]=1.08[0.87-1.33], p=0.478). Similar results were obtained when considering different HF categories based on left ventricular ejection fraction.

CONCLUSIONS:

Women and men exhibited distinct clinical profiles. Although this may have had an impact on hospital pathways (non-cardiology/cardiology units) and pharmacological prescriptions, sex per se did not appear as an independent determinant of clinical choices. Moreover, when considering homogeneous groups, women were not undertreated. Finally, female sex was not associated with worse clinical outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am Heart J Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am Heart J Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos