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Association of computed tomography-derived pectoralis muscle area and density with disease severity and respiratory symptoms in patients with chronic obstructive pulmonary disease: A case-control study.
Li, Can; Lian, Xinying; He, Jingchun; Gao, Xiao; Liu, Xuehuan; Bao, Cuiping; Li, Zuoxi; Cui, Weiwei; Yu, Li; Liu, Jun.
Afiliación
  • Li C; The Fourth Central Clinical School, Tianjin Medical University, Tianjin, 300140, China.
  • Lian X; The Fourth Central Clinical School, Tianjin Medical University, Tianjin, 300140, China.
  • He J; Department of Respiratory and Critical Care Medicine, Tianjin Fourth Central Hospital, Tianjin, 300140, China.
  • Gao X; Department of Radiology, Tianjin Fourth Central Hospital, Tianjin, 300140, China.
  • Liu X; Department of Radiology, Tianjin Union Medical Center, Tianjin, 300121, China.
  • Bao C; Department of Radiology, Tianjin Union Medical Center, Tianjin, 300121, China.
  • Li Z; The Fourth Central Clinical School, Tianjin Medical University, Tianjin, 300140, China.
  • Cui W; The Fourth Central Clinical School, Tianjin Medical University, Tianjin, 300140, China.
  • Yu L; Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
  • Liu J; The Fourth Central Clinical School, Tianjin Medical University, Tianjin, 300140, China. Electronic address: cjr.liujun@vip.163.com.
Respir Med ; 233: 107783, 2024 11.
Article en En | MEDLINE | ID: mdl-39209127
ABSTRACT
RATIONALE AND

OBJECTIVES:

Computed tomography (CT) is commonly used and offers an additional viewpoint for evaluating extrapulmonary symptoms, disease severity, and muscle atrophy. This study assessed whether the pectoralis muscle area (PMA) and pectoralis muscle density (PMD) are lower in patients with chronic obstructive pulmonary disease (COPD) than in healthy controls and elucidated their relationships with these variables. MATERIALS AND

METHODS:

The participants were enrolled in the hospital outpatient clinic between October 2023 and May 2024. Information was obtained from questionnaires, lung function, and CT imaging findings. On full-inspiratory CT, the PMA and PMD were measured at the aortic arch level using predetermined attenuation ranges of -29 and 150 Hounsfield units. We observed lower PMA and PMD and evaluated their associations with lung function, respiratory symptoms, and CT imaging findings in patients with COPD.

RESULTS:

Overall, 120 participants were enrolled at baseline (60 healthy controls and 60 patients with COPD). PMA and PMD were lower with progressive airflow limitation severity in those with COPD. The degree of emphysema and air trapping, as well as lung function, were correlated with PMA and PMD (P < 0.05), although not with the COPD Assessment Test or modified Medical Research Council scores (P > 0.05).

CONCLUSION:

Participants with COPD had smaller PMA and PMD. These measurements were correlated with the severity of airflow limitation, lung function, emphysema, and air trapping, suggesting that these features of the pectoralis muscle obtained from CT are helpful in assessments of patients with COPD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Músculos Pectorales / Índice de Severidad de la Enfermedad / Tomografía Computarizada por Rayos X / Enfermedad Pulmonar Obstructiva Crónica Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Músculos Pectorales / Índice de Severidad de la Enfermedad / Tomografía Computarizada por Rayos X / Enfermedad Pulmonar Obstructiva Crónica Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido