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Refining hemodynamic correction in in vivo wide-field fluorescent imaging through linear regression analysis.
Li, Jing; Yang, Fan; Zhang, Kathleen; Wu, Shiqiang; Niemeyer, James; Zhao, Mingrui; Luo, Peijuan; Li, Nan; Li, Rongxin; Li, Dan; Lin, Weihong; Liou, Jyun-You; Schwartz, Theodore H; Ma, Hongtao.
Afiliación
  • Li J; Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA.
  • Yang F; Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA.
  • Zhang K; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA; Stuyvesant High School, New York, New York 10282, USA.
  • Wu S; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA; Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 43
  • Niemeyer J; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA.
  • Zhao M; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA.
  • Luo P; Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA.
  • Li N; Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
  • Li R; Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
  • Li D; Department of Radiology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
  • Lin W; Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: linwh@jlu.edu.cn.
  • Liou JY; Department of Anesthesiology, Weill Cornell Medicine, New York, New York, NY 10065, USA.
  • Schwartz TH; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA. Electronic address: schwarh@med.cornell.edu.
  • Ma H; Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, 525 East 68th Street, Box 99, New York, NY 10065, USA. Electronic address: hom2001@med.cornell.edu.
Neuroimage ; 299: 120816, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-39209071
ABSTRACT
Accurate interpretation of in vivo wide-field fluorescent imaging (WFFI) data requires precise separation of raw fluorescence signals into neural and hemodynamic components. The classical Beer-Lambert law-based approach, which uses concurrent 530-nm illumination to estimate relative changes in cerebral blood volume (CBV), fails to account for the scattering and reflection of 530-nm photons from non-neuronal components leading to biased estimates of CBV changes and subsequent misrepresentation of neural activity. This study introduces a novel linear regression approach designed to overcome this limitation. This correction provides a more reliable representation of CBV changes and neural activity in fluorescence data. Our method is validated across multiple datasets, demonstrating its superiority over the classical approach.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemodinámica Límite: Animals / Humans / Male Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemodinámica Límite: Animals / Humans / Male Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos