Joint identity among loci under mutation and regular inbreeding.
Theor Popul Biol
; 159: 74-90, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39208993
ABSTRACT
This study describes a compact method for determining joint probabilities of identity-by-state (IBS) within and between loci in populations evolving under genetic drift, crossing-over, mutation, and regular inbreeding (partial self-fertilization). Analogues of classical indices of associations among loci arise as functions of these joint identities. This coalescence-based analysis indicates that multi-locus associations reflect simultaneous coalescence events across loci. Measures of association depend on genetic diversity rather than allelic frequencies, as do linkage disequilibrium and its relatives. Scaled indices designed to show monotonic dependence on rates of crossing-over, inbreeding, and mutation may prove useful for interpreting patterns of genome-scale variation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endogamia
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
Theor Popul Biol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos