Ball-Milling-Enabled Nickel-Catalyzed Reductive 1,4-Alkylarylation of 1,3-Enynes under an Air Atmosphere.

Lei, Hao; Wang, Bobo; Yang, Yufang; Fan, Shu; Wang, Siyuan; Wei, Xiaofeng

Lei, Hao; Wang, Bobo; Yang, Yufang; Fan, Shu; Wang, Siyuan; Wei, Xiaofeng.

Afiliación

Lei H; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen 518118, China.
Wang B; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.
Yang Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Fan S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Wang S; Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710061, China.
Wei X; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen 518118, China.

Org Lett ; 26(36): 7688-7694, 2024 Sep 13.

Article en En | MEDLINE | ID: mdl-39207781

ABSTRACT

ABSTRACT

A ball-mill-enabled nickel-catalyzed 1,4-alkylarylation of 1,3-enynes with organic bromides has been developed, offering a versatile method for assembling tetrasubstituted allenes. This approach, the first of ball-milling-based remote radical coupling, overcomes the limitations of traditional solution-phase methods, such as the need for air- and moisture-sensitive reagents, the use of bulk solvents, and prolonged reaction times. Given the outstanding performance of ball-milling-based radical reduction coupling reactions, we anticipate further advancements in sustainable and efficient synthetic methodologies.

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google