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Voxel-based dosimetry with integrated Y-90 PET/MRI and prediction of response of primary and metastatic liver tumors to radioembolization with Y-90 glass microspheres.
Demir, Burak; Soydal, Cigdem; Kucuk, Nuriye Ozlem; Celebioglu, Emre Can; Bilgic, Mehmet Sadik; Kuru Oz, Digdem; Elhan, Atilla Halil; Kir, Kemal Metin.
Afiliación
  • Demir B; Department of Nuclear Medicine, Ankara University Medical School, Ankara, Turkey. 4burakfe@gmail.com.
  • Soydal C; Department of Nuclear Medicine, Ankara University Medical School, Ankara, Turkey.
  • Kucuk NO; Department of Nuclear Medicine, Ankara University Medical School, Ankara, Turkey.
  • Celebioglu EC; Department of Radiology, Ankara University Medical School, Ankara, Turkey.
  • Bilgic MS; Department of Radiology, Ankara University Medical School, Ankara, Turkey.
  • Kuru Oz D; Department of Radiology, Ankara University Medical School, Ankara, Turkey.
  • Elhan AH; Department of Biostatistics, Ankara University Medical School, Ankara, Turkey.
  • Kir KM; Department of Nuclear Medicine, Ankara University Medical School, Ankara, Turkey.
Ann Nucl Med ; 2024 Aug 29.
Article en En | MEDLINE | ID: mdl-39207630
ABSTRACT

PURPOSE:

In this study, we aimed to evaluate the response of the primary and metastatic liver tumors to radioembolization with 90Y glass microspheres and investigate its correlations with dosimetric variables calculated with 90Y PET/MRI.

METHODS:

In this ambispective study, 44 patients treated with 90Y glass microspheres and imaged with 90Y PET/MRI were included for analysis. Dosimetric analysis was performed for every perfused lesion using dose-volume histograms. Response was assessed by comparing pre-treatment and follow-up total lesion glycolysis (TLG) values derived from 18F-FDG PET imaging. The relationship between ΔTLG and log-transformed dosimetric variables was analyzed with linear mixed effects regression models. ROC analyses were performed to compare discriminatory power of the variables in predicting response and complete response.

RESULTS:

Regression and ROC analyses demonstrated that mean tumor dose and almost all D values were statistically significant predictors of treatment response and complete treatment response. Specifically, D60, D70 and D80 values exhibited significantly higher discriminatory power for predicting treatment response compared to the mean dose (Dmean) delivered to tumor. High specificity cut-off values to predict response were determined as 160.75 Gy for Dmean, 95.50 Gy for D60, 89 Gy for D70, and 59.50 Gy for D80. Similarly, high-specificity cut-off values to predict complete response were 262.75 Gy for Dmean, 173 Gy for D70, 140.5 Gy for D80, and 100 Gy for D90.

CONCLUSION:

In this study, we demonstrated that voxel-based dosimetry with post-treatment 90Y PET/MRI can predict response to treatment. D60, D70 and D80 variables also did have greater discriminatory power compared to Dmean in prediction of response. In addition, we present high-specificity cut-offs to predict response (CR + PR) and complete response (CR) for both Dmean and several D variables derived from dose-volume histograms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Nucl Med Asunto de la revista: MEDICINA NUCLEAR Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Nucl Med Asunto de la revista: MEDICINA NUCLEAR Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Japón