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The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives.
Mohamed, Wael; Eltantawi, Mohamed Abdelhalim; Agarwal, Vidhu; Bandres-Ciga, Sara; Makarious, Mary B; Mecheri, Yasser; Zewde, Yared Zenebe; Kamel, Walaa A; Al-Mubarak, Bashayer; Alzoubi, Karem H; Kissani, Najib; Alghamdi, Badrah S; Sassi, Samia Ben.
Afiliación
  • Mohamed W; Basic Medical Science Department, Kulliyyah of Medicine, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.
  • Eltantawi MA; Clinical Pharmacology Department, Menoufia Medical School, Menoufia University, 3211 Menoufia, Egypt.
  • Agarwal V; Department of Neurology, Faculty of Medicine, Delta University for Science and Technology, 11152 Gamasa, Egypt.
  • Bandres-Ciga S; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA.
  • Makarious MB; Centre for Alzheimer's Disease and Related Dementias (CARD), National Institute on Ageing (NIA), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Mecheri Y; Centre for Alzheimer's Disease and Related Dementias (CARD), National Institute on Ageing (NIA), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Zewde YZ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, WC1N 3BG London, UK.
  • Kamel WA; Neurology Department, Dr Benbadis University Hospital, 25000 Constantine, Algeria.
  • Al-Mubarak B; Department of Neurology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
  • Alzoubi KH; Department of Neurology, Beni-Suef University, 62511 Beni-Suef, Egypt.
  • Kissani N; King Faisal Specialist Hospital and Research Center, 11564 Riyadh, Saudi Arabia.
  • Alghamdi BS; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, 27272 Sharjah, United Arab Emirates.
  • Sassi SB; Department of Neurology, Marrakech Faculty of Medicine and Pharmacy, University Hospital Mohamed VI, 5244 Marrakech, Morocco.
J Integr Neurosci ; 23(8): 152, 2024 Aug 19.
Article en En | MEDLINE | ID: mdl-39207075
ABSTRACT
Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Revista: J Integr Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Revista: J Integr Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Singapur