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Viability of Whole-Slide Imaging for Intraoperative Touch Imprint Cytological Diagnosis of Axillary Sentinel Lymph Nodes in Breast Cancer Patients.
Ren, Fei; Li, Huange; Yang, Wentao; Chen, Ying; Zheng, Yuwei; Zhang, Hao; Zhou, Shuling; Ping, Bo; Shi, Peng; Wan, Xiaochun; Wang, Yanli.
Afiliación
  • Ren F; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Li H; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Yang W; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Chen Y; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zheng Y; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Zhang H; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhou S; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Ping B; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Shi P; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Wan X; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wang Y; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Diagn Cytopathol ; 2024 Aug 29.
Article en En | MEDLINE | ID: mdl-39206735
ABSTRACT

BACKGROUND:

Whole-slide imaging (WSI) is a promising tool in pathology. However, the use of WSI in cytopathology has lagged behind that in histology. We aimed to evaluate the utility of WSI for the intraoperative touch imprint cytological diagnosis of axillary sentinel lymph nodes (SLNs) in breast cancer patients.

METHODS:

Glass slides from touch imprint cytology of 480 axillary SLNs were scanned using two different WSI scanners. The intra- and interobserver concordance, accuracy, possible reasons for misdiagnosis, scanning time, and review time for three cytopathologists were compared between WSI and light microscopy (LM).

RESULTS:

A total of 4320 diagnoses were obtained. There was substantial to strong intraobserver concordance when comparing reads among paired LM slides and WSI digital slides (κ coefficient ranged from 0.63 to 0.88, and concordance rates ranged from 94.58% to 98.33%). Substantial to strong interobserver agreement was also observed among the three cytopathologists (κ coefficient ranged from 0.67 to 0.85, and concordance rates ranged from 95.42% to 97.92%). The accuracy of LM was slightly higher (average of 98.06%) than that of WSI (averages of 96.81% and 97.78%). The majority of misdiagnoses were false negative diagnoses due to the following top three causes few cancer cells, confusing cancer cells with histiocytes, and confusing cancer cells with lymphocytes.

CONCLUSIONS:

This study is the first to address the feasibility of WSI in touch imprint cytology. The use of WSI for intraoperative touch imprint cytological diagnosis of SLNs is a practical option when experienced staff are not available on-site.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagn Cytopathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagn Cytopathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos