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IgA vasculitis induced by carboplatin + nab-paclitaxel + pembrolizumab in a patient with advanced lung squamous cell carcinoma: a case report.
Terashima, Yuto; Matsumoto, Masaru; Ozaki, Saeko; Nakagawa, Michiko; Nakagome, Shun; Terasaki, Yasuhiro; Iida, Hiroki; Mitsugi, Ryotaro; Kuramochi, Eri; Okada, Naoko; Inoue, Tomoyasu; Matsuki, Satoru; Kitagawa, Shingo; Fukuizumi, Aya; Onda, Naomi; Takeuchi, Susumu; Miyanaga, Akihiko; Kasahara, Kazuo; Seike, Masahiro.
Afiliación
  • Terashima Y; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Matsumoto M; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Ozaki S; Department of Dermatology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Nakagawa M; Department of Dermatology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Nakagome S; Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Terasaki Y; Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Iida H; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Mitsugi R; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Kuramochi E; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Okada N; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Inoue T; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Matsuki S; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Kitagawa S; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Fukuizumi A; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Onda N; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Takeuchi S; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Miyanaga A; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Kasahara K; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
  • Seike M; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Front Immunol ; 15: 1370972, 2024.
Article en En | MEDLINE | ID: mdl-39206190
ABSTRACT
A 73-year-old man with lung squamous cell carcinoma was administered carboplatin + nab-paclitaxel + pembrolizumab for four cycles. Subsequently, he presented with multiple purpuras on his extremities, joint swelling on his fingers, abdominal pain, and diarrhea, accompanied by acute kidney injury (AKI), increased proteinuria, hematuria, and elevated C-reactive protein levels. Skin biopsy showed leukocytoclastic vasculitis as well as IgA and C3 deposition in the vessel walls. Based on these findings, the patient was diagnosed with IgA vasculitis as an immune-related adverse event (irAE) induced by carboplatin + nab-paclitaxel + pembrolizumab. After discontinuation of pembrolizumab and glucocorticoids, the symptoms immediately resolved. Regular monitoring of skin, blood tests, and urinalysis are necessary, and the possibility of irAE IgA vasculitis should be considered in cases of purpura and AKI during treatment with immune checkpoint inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Carboplatino / Paclitaxel / Albúminas / Anticuerpos Monoclonales Humanizados / Neoplasias Pulmonares Límite: Aged / Humans / Male Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Protocolos de Quimioterapia Combinada Antineoplásica / Carboplatino / Paclitaxel / Albúminas / Anticuerpos Monoclonales Humanizados / Neoplasias Pulmonares Límite: Aged / Humans / Male Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza