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Preoperative Autologous Blood Donation for Rh-Negative Pregnant Women Undergoing Cesarean Sections.
Wannoon, Siriwan; Saringkanan, Parinya; Boonhok, Rachasak; Kooltheat, Nateelak; Charong, Nurdina.
Afiliación
  • Wannoon S; Department of Medical Technology and Clinical Pathology, Takuapa Hospital, Phang Nga, Thailand.
  • Saringkanan P; Department of Obstretics and Gynecology, Takuapa Hospital, Phang Nga, Thailand.
  • Boonhok R; School of Allied Health Sciences, and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat, Thailand.
  • Kooltheat N; Department of Medical Technology, Walailak University, Nakhon Si Thammarat 80161, Thailand.
  • Charong N; School of Allied Health Sciences, and Hematology and Transfusion Science Research Center, Walailak University, Nakhon Si Thammarat, Thailand.
J Clin Med Res ; 16(7-8): 335-344, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39206108
ABSTRACT

Background:

Cesarean sections (C-section) often require blood transfusions in cases of severe bleeding, particularly challenging in Rh-negative pregnancies due to the scarcity of Rh-negative donors, with only approximately 0.3% of the population in Thailand. Autologous blood donation, where individuals donate their own blood before surgery, offers a promising solution. Our study focused on preparing preoperative autologous blood donations (PAD) for Rh-negative pregnancies.

Methods:

We conducted blood screening on 7,182 pregnancies at Takuapa Hospital from October 2013 to September 2018, identifying 21 Rh-negative pregnant women. We established criteria based on hemoglobin (Hb) levels, which are crucial for autologous blood preparation (Hb at 11.0 g/dL, and hematocrit (Hct) above 33%). Blood samples were collected twice during pregnancy, at 36 and 37 weeks, with the second collection 1 week before the C-section. Pregnancies testing positive for infectious markers were excluded following standard blood donation guidelines. Twelve pregnant women testing negative for infectious markers were enrolled.

Results:

The demographic data showed 12 subjects aged 17 to 41 years, with an average of 27.83. Initial blood tests indicated Hb and Hct levels of 12.5 g/dL, and 36.4%, slightly decreasing to 12.2 g/dL and 35.8% in the second collection. On the day of the cesarean, levels further declined to 11.6 g/dL and 34.4%, respectively, within normal ranges. At discharge, the Hct measured 34.8%. Maternal and infant health post-C-section were good, with baby weights ranging from 2,640 to 4,080 g. None of the 12 cases required autologous blood transfusion, validating the safety of standard autologous blood preparation practices.

Conclusions:

This study highlights the safety of autologous blood donation for pregnant women with rare blood types, which was achieved through effective planning and collaboration among hospital departments. These findings can serve as a model for other hospitals and significantly reduce the burden of searching for Rh-negative donors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Res Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Res Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Canadá