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A Jaw-Dropping Consequence: Nintedanib's Role in Osteonecrosis of the Jaw.
Rai, Oshin; Romero, Kaitlyn N; Shaykh, Natalie; Caldas, Ricardo; Tripathi, Vanshika; Padilla, Rebekah M; Karan, Abhinav; Guo, Hui Jun; Jacob, Rafik.
Afiliación
  • Rai O; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Romero KN; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Shaykh N; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Caldas R; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Tripathi V; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Padilla RM; Diagnostic Radiology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Karan A; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Guo HJ; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
  • Jacob R; Program for Adults with Intellectual and Developmental Disabilities, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Cureus ; 16(7): e65689, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39205781
ABSTRACT
Nintedanib, a tyrosine kinase inhibitor, is a cornerstone in the management of idiopathic pulmonary fibrosis through its anti-fibrotic effects; however, its impact on wound healing is less studied. We present a case of medication-related osteonecrosis of the jaw (MRONJ) following the initiation of nintedanib. The patient's presentation prompted a drug holiday of nintedanib, resulting in a marked improvement in her symptoms. MRONJ is a disease requiring a high index of suspicion, and the number of inciting medications continues to rise. Nintedanib, as an inhibitor of angiogenesis, may have contributed to poor wound healing following dental extraction, subsequently leading to MRONJ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos