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Contraceptive effect of a gonadotropin-releasing hormone vaccine on captive male brown bears (Ursus arctos).
Matsumoto, Naoya; Tomiyasu, Jumpei; Hagino, Kyogo; Matsui, Motozumi; Yanagawa, Yojiro.
Afiliación
  • Matsumoto N; Azabu University, Sagamihara, Kanagawa, Japan.
  • Tomiyasu J; Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
  • Hagino K; Noboribetsu Bear Park, Noboribetsu, Hokkaido, Japan.
  • Matsui M; Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
  • Yanagawa Y; Hokkaido University, Sapporo, Hokkaido, Japan.
Reprod Domest Anim ; 59(9): e14707, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39205472
ABSTRACT
Fertility control has traditionally been applied in zoos to control captive populations, and reversible contraception is important. However, contraceptive methods for male bears have not been reported. We aimed to establish a reversible contraceptive for male brown bears by investigating the effects of a gonadotropin-releasing hormone (GnRH) vaccine (Improvac®) that was developed for the immune castration of pigs. We vaccinated six bears with two sequential doses of 400 (n = 2) or 600 µg Improvac® (n = 4) with a 1-month interval during the pre-breeding season (February to April). We compared the reproductive parameters (testosterone levels and semen parameters) of the six vaccinated and four non-vaccinated (control) bears once during the breeding season (May or June). To investigate whether the reproductive performance could be restored in the following year of contraception, we also compared the reproductive parameters once during the breeding season in two bears between the year with GnRH vaccination and the following year without vaccination. Vaccination treatments suppressed reproductive parameters in 5 bears, although vaccination with 400 µg of Improvac® was not effective in one bear. Testosterone levels and the rate of progressive sperm motility were significantly lower, and total sperm count and testis size tended to be lower in vaccinated bears, compared with the controls. Blood biochemical findings and direct observations after Improvac® vaccination did not reveal side effects. Moreover, testosterone levels and spermatogenic scores of two bears were restored in the following year. We confirmed that the Improvac® vaccine elicited a reversible contraceptive effect in male brown bears.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Ursidae / Hormona Liberadora de Gonadotropina / Vacunas Anticonceptivas Límite: Animals Idioma: En Revista: Reprod Domest Anim Asunto de la revista: MEDICINA REPRODUTIVA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Ursidae / Hormona Liberadora de Gonadotropina / Vacunas Anticonceptivas Límite: Animals Idioma: En Revista: Reprod Domest Anim Asunto de la revista: MEDICINA REPRODUTIVA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania