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Identification of Risk Factors for Primary Osteoporosis: The Role of Cervical Ligament Ossification.
Wang, Dongping; Yang, Jiamin; Li, Haishan; Chen, Yuxian; Lin, Wei; Lei, Shenglin; You, Yawen; Liu, Chang; Lin, Yuewei; Guo, Huizhi; Mo, Guoye; Tang, Yongchao; Yuan, Kai; Deng, Wei; Liu, Teng; Gu, Guoning; Mai, Bin; Zhang, Zhen; Zhang, Shuncong; Li, Yongxian.
Afiliación
  • Wang D; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Yang J; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Li H; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Chen Y; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Lin W; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Lei S; The Shenzhen Clinical College of Medicine of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
  • You Y; The Fifth Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Liu C; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Lin Y; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Guo H; Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Mo G; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, Guangdong, China.
  • Tang Y; Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Yuan K; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, Guangdong, China.
  • Deng W; Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Liu T; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, Guangdong, China.
  • Gu G; Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Mai B; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, Guangdong, China.
  • Zhang Z; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Zhang S; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Li Y; The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Med Sci Monit ; 30: e944963, 2024 Aug 29.
Article en En | MEDLINE | ID: mdl-39205372
ABSTRACT
BACKGROUND Long-term clinical practice has suggested a possible association between ossification of cervical ligament (OCL) and primary osteoporosis (POP). However, there is a lack of relevant research data. This study aimed to clarify the potential relationship between OCL and POP, and propose new strategies for preventing the onset of POP. MATERIAL AND METHODS The study involved 107 patients. The patients' diagnosis included OCL (ossification of the posterior longitudinal ligament, ossification of the ligamentum flavum, and ossification of the nuchal ligament) and POP. Bone mineral density (BMD), types of OCL, types of ossification of posterior longitudinal ligament, age, sex, serum calcium, serum phosphorus, alkaline phosphatase, type I collagen amino-terminal extension peptide, type I collagen degradation products, osteocalcin N-terminal molecular fragments, 25-hydroxyvitamin D, and history of taking steroid drugs were collected. SPSS24.0 and GraphPad Prism 8 were used to obtain the risk factors for POP. RESULTS One-way analysis of variance found that OCL, ossification of posterior longitudinal ligament, alkaline phosphatase, and osteocalcin N-terminal molecular fragments had statistical significance on BMD of the femoral neck (P<0.05). The independent sample t test showed that patient sex had statistical significant effect on BMD (femoral neck) (P=0.036). Incorporating the above factors into multiple linear regression analysis, it was found that OCL, alkaline phosphatase, and osteocalcin N-terminal molecular fragments were risk factors affecting BMD of femoral neck (P<0.05). CONCLUSIONS OCL, osteocalcin N-terminal molecular fragments, and alkaline phosphatase are risk factors for POP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Densidad Ósea / Osteocalcina / Osificación del Ligamento Longitudinal Posterior / Fosfatasa Alcalina Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Densidad Ósea / Osteocalcina / Osificación del Ligamento Longitudinal Posterior / Fosfatasa Alcalina Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos