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Associations between brain structure and dual decline in gait and cognition.
Karunarathna, Sadhani; Breslin, Monique; Alty, Jane; Beare, Richard; Collyer, Taya A; Srikanth, Velandai K; McDonald, James Scott; Callisaya, Michele L.
Afiliación
  • Karunarathna S; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
  • Breslin M; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
  • Alty J; Wicking Dementia Research and Education Centre, University of Tasmania, Tasmania, Australia; School of Medicine, University of Tasmania, Hobart, Tasmania, Australia; Royal Hobart Hospital, Hobart, Tasmania, Australia.
  • Beare R; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia; National Centre for Healthy Ageing, Melbourne, Victoria, Australia; Developmental Imaging, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.
  • Collyer TA; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia; National Centre for Healthy Ageing, Melbourne, Victoria, Australia.
  • Srikanth VK; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia; National Centre for Healthy Ageing, Melbourne, Victoria, Australia; Departments of Medicine and Geriatric Medicine, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia.
  • McDonald JS; Wicking Dementia Research and Education Centre, University of Tasmania, Tasmania, Australia; Royal Hobart Hospital, Hobart, Tasmania, Australia.
  • Callisaya ML; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia; National Centre for Healthy Ageing, Melbourne, Victoria, Australia. Electronic address: michele.callisay
Neurobiol Aging ; 143: 10-18, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39205368
ABSTRACT
Dual decline in gait and cognition is associated with an increased risk of dementia, with combined gait and memory decline exhibiting the strongest association. To better understand the underlying pathology, we investigated the associations of baseline brain structure with dual decliners using three serial gait speed and cognitive assessments in memory, processing speed-attention, and verbal fluency. Participants (n=267) were categorized based on annual decline in gait speed and cognitive measures. Lower gray and white matter volume and higher white matter hyperintensity volume increased the risk of being a dual decliner in gait and both the memory and processing speed-attention groups (all p < 0.05). Lower hippocampal volume (p = 0.047) was only associated with dual decline in gait and memory group. No brain structures were correlated with dual decline in gait and verbal fluency. These results suggest that neurodegenerative pathology and white matter hyperintensities are involved in dual decline in gait and both memory and processing speed-attention. Smaller hippocampal volume may only contribute to dual decline in gait and memory.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Cognición / Sustancia Blanca / Marcha / Hipocampo / Memoria Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neurobiol Aging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Cognición / Sustancia Blanca / Marcha / Hipocampo / Memoria Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neurobiol Aging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos