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3D-printed silicate porous bioceramics promoted the polarization of M2-macrophages that enhanced the angiogenesis in bone regeneration.
Zang, Chengwu; Che, Min; Xian, Hang; Xiao, Xin; Li, Tengfei; Chen, Yongxiang; Liu, Yaxiong; Cong, Rui.
Afiliación
  • Zang C; Department of Orthopedics, Xijing Hospital, the Air Force Medical University, Xi'an, China.
  • Che M; Affiliated Central Hospital of Shenyang Medical College, Shenyang, China.
  • Xian H; Department of Orthopedics, Xijing Hospital, the Air Force Medical University, Xi'an, China.
  • Xiao X; Department of Orthopedics, Xijing Hospital, the Air Force Medical University, Xi'an, China.
  • Li T; The North West Institute of Nuclear Technology, Xi'an, China.
  • Chen Y; Department of Orthopedics, Xijing Hospital, the Air Force Medical University, Xi'an, China.
  • Liu Y; Jihua Laboratory, Foshan, China.
  • Cong R; Department of Orthopedics, Xijing Hospital, the Air Force Medical University, Xi'an, China.
J Biomed Mater Res B Appl Biomater ; 112(9): e35469, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39205328
ABSTRACT
The failure of bone regeneration has been considered as a serious problem that troubling patients for decades, most of which was resulted by the poor angiogenesis and chronic inflammation after surgery. Among multiple materials applied in the repair of bone defect, silicate bioceramics attracted researchers because of its excellent bioactivity. The purpose of this study was to detect the effect of specific bioactive glass ceramic (AP40, based on crystalline phases of apatite and wollastonite) on angiogenesis and the subsequent bone growth through the modulation of macrophages. Two groups were included in this study control group (macrophages without any stimulation, denominated as Control) and AP40 group (macrophages incubated on AP40). This study investigated the effect of AP40 on macrophages polarization (RAW264.7) and angiogenesis in vitro and in vivo. Additionally, the changes of angiogenic ability regulated by macrophages were explored. AP40 showed excellent angiogenesis potential and the expression of CD31 was promoted through the modulation of macrophages toward M2 subtype. Additionally, the macrophages incubated on AP40 synthesized more PDGF-BB comparing to macrophages without any stimulation, which contributed to the improved angiogenetic ability of human umbilical vein endothelial cells (HUVECs). Results of in vivo studies indicated increased bone ingrowth along the implants, which indicated the potential of bioceramics for bone defect repair clinically.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración Ósea / Cerámica / Silicatos / Neovascularización Fisiológica / Células Endoteliales de la Vena Umbilical Humana / Impresión Tridimensional / Macrófagos Límite: Animals / Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración Ósea / Cerámica / Silicatos / Neovascularización Fisiológica / Células Endoteliales de la Vena Umbilical Humana / Impresión Tridimensional / Macrófagos Límite: Animals / Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos