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Polyene-Based Derivatives with Antifungal Activities.
Ngece, Kwanele; Ntondini, Thabisa L; Khwaza, Vuyolwethu; Paca, Athandwe M; Aderibigbe, Blessing A.
Afiliación
  • Ngece K; Department of Chemistry, University of Fort Hare, Alice 5700, Eastern Cape, South Africa.
  • Ntondini TL; Department of Chemistry, University of Fort Hare, Alice 5700, Eastern Cape, South Africa.
  • Khwaza V; Department of Chemistry, University of Fort Hare, Alice 5700, Eastern Cape, South Africa.
  • Paca AM; Department of Chemistry, University of Fort Hare, Alice 5700, Eastern Cape, South Africa.
  • Aderibigbe BA; Department of Chemistry, University of Fort Hare, Alice 5700, Eastern Cape, South Africa.
Pharmaceutics ; 16(8)2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39204411
ABSTRACT
Polyenes are a class of organic compounds well known for their potent antifungal properties. They are effective due to their ability to target and disrupt fungal cell membranes by binding to ergosterol and forming pores. Despite their effectiveness as antifungal drugs, polyenes have several limitations, such as high toxicity to the host cell and poor solubility in water. This has prompted ongoing research to develop safer and more efficient derivatives to overcome such limitations while enhancing their antifungal activity. In this review article, we present a thorough analysis of polyene derivatives, their structural modifications, and their influence on their therapeutic effects against various fungal strains. Key studies are discussed, illustrating how structural modifications have led to improved antifungal properties. By evaluating the latest advancements in the synthesis of polyene derivatives, we highlight that incorporating amide linkers at the carboxylic moiety of polyene molecules notably improves their antifungal properties, as evidenced by derivatives 4, 5, 6G, and 18. This review can help in the design and development of novel polyene-based compounds with potent antifungal activities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Suiza