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Vicia faba L. Pod Valves: A By-Product with High Potential as an Adjuvant in the Treatment of Parkinson's Disease.
Tesoro, Carmen; Lelario, Filomena; Piscitelli, Fabiana; Di Capua, Angela; Della Sala, Paolo; Montoro, Paola; Bianco, Giuliana; Acquavia, Maria Assunta; Dell'Agli, Mario; Piazza, Stefano; Ciriello, Rosanna.
Afiliación
  • Tesoro C; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
  • Lelario F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
  • Piscitelli F; Endocannabinoid Research Group, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), 80078 Pozzuoli, Italy.
  • Di Capua A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
  • Della Sala P; Department of Chemistry and Biology, University of the Study of Salerno, 84084 Fisciano, Italy.
  • Montoro P; Department of Pharmacy, University of the Study of Salerno, 84084 Fisciano, Italy.
  • Bianco G; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
  • Acquavia MA; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
  • Dell'Agli M; Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, 20133 Milan, Italy.
  • Piazza S; Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, 20133 Milan, Italy.
  • Ciriello R; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Molecules ; 29(16)2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39203021
ABSTRACT
Vicia faba L. is a leguminous plant with seeds rich in nutritional compounds, such as polyphenols and L-dopa, a dopamine precursor and first-line treatment for Parkinson's symptoms. Recently, its by-products have been revalued as a sustainable source of bioactive compounds. In this study, aqueous extracts of Lucan broad bean pod valves (BPs) were characterized to evaluate their potential use as adjuvants in severe Parkinson's disease. L-dopa content, quantified by LC-UV, was much higher in BPs than in seeds (28.65 mg/g dw compared to 0.76 mg/g dw). In addition, vicine and convicine, the metabolites responsible for favism, were not detected in pods. LC-ESI/LTQ-Orbitrap/MS2 allowed the identification of the major polyphenolic compounds, including quercetin and catechin equivalents, that could ensure neuroprotection in Parkinson's disease. ESI(±)-FT-ICR MS was used to build 2D van Krevelen diagrams; polyphenolic compounds and carbohydrates were the most representative classes. The neuroprotective activity of the extracts after MPP+-induced neurotoxicity in SH-SY5Y cells was also investigated. BP extracts were more effective than synthetic L-dopa, even at concentrations up to 100 µg/mL, due to the occurrence of antioxidants able to prevent oxidative stress. The stability and antioxidant component of the extracts were then emphasized by using naturally acidic solutions of Punica granatum L., Ribes rubrum L., and gooseberry (Phyllanthus emblica L.) as extraction solvents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Semillas / Extractos Vegetales / Vicia faba Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Semillas / Extractos Vegetales / Vicia faba Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza